ArticlePhysiology & behavior2015
Poor quality of life, depressed mood, and memory impairment may be mediated by sleep disruption in patients with Addison's disease.
Article in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Health-related quality of life and patterns of psychological vulnerability in autoimmune Addison's disease: a systematic review.Frontiers in endocrinology · 2026Pooled it
- Long-term safety of once-daily, dual-release hydrocortisone in patients with adrenal insufficiency: a phase 3b, open-label, extension study.European journal of endocrinology · 2017Trial
- Work Loss and Income Before and After Diagnosis of Addison's Disease: A Population-Based Longitudinal Study.The Journal of clinical endocrinology and metabolism · 2026Article
- Cognitive Assessment in Adults With Adrenal Cortisol Insufficiency: Challenges and Opportunities.Endocrine reviews · 2026Review
- Article
- The Relationship Between Sleep, Fatigue and Quality of Life in Young Adults With Autoimmune Addison's Disease.Clinical endocrinology · 2025Article
- Evaluation of Sleep Health in Children With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.The Journal of clinical endocrinology and metabolism · 2025Article
- Glucocorticoids and cognitive function: a walkthrough in endogenous and exogenous alterations.Journal of endocrinological investigation · 2023Review
- Glucocorticoid Withdrawal Symptoms and Quality of Life in Patients with Systemic Lupus Erythematosus.International journal of rheumatology · 2023Article
- Glucocorticoid replacement therapy for primary and secondary adrenal insufficiency and their impact on cognition.Frontiers in endocrinology · 2023Review
- Poor quality of life and sleep in patients with adrenal insufficiency-another cause of increased mortality?Irish journal of medical science · 2022Article
- The hidden link between circadian entropy and mental health disorders.Translational psychiatry · 2022Review
- A metabolomics approach identified toxins associated with uremic symptoms in advanced chronic kidney disease.Kidney international · 2022Article
- Characteristics and Challenges of Primary Adrenal Insufficiency in Africa: A Review of the Literature.International journal of endocrinology · 2022Review
- Sleep, Cognition and Cortisol in Addison's Disease: A Mechanistic Relationship.Frontiers in endocrinology · 2021Review
- Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update.Frontiers in neurology · 2021Review
- Sleep quality and its impacts on quality of life among military personnel in remote frontier areas and extreme cold environments.Health and quality of life outcomes · 2020Article
- Novel insights into glucocorticoid replacement therapy for pediatric and adult adrenal insufficiency.Therapeutic advances in endocrinology and metabolism · 2019Review
- Longitudinal AddiQoL scores may identify higher risk for adrenal crises in Addison's disease.Endocrine · 2018Article
- Better Sleep in a Strange Bed? Sleep Quality in South African Women with Posttraumatic Stress Disorder.Frontiers in psychology · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Standard replacement therapy for Addison's disease (AD) does not restore a normal circadian rhythm. In fact, hydrocortisone replacement in AD patients likely induces disrupted sleep. Given that healthy sleep plays an important role in improving quality of life, optimizing cognition, and ensuring affect regulation, the aim of this study was to investigate whether poor quality of life, mood alterations, and memory complaints reported by AD patients are associated with their disrupted sleep patterns. Sixty patients with AD and 60 matched healthy controls completed a battery of self-report questionnaires assessing perceived physical and mental health (Short-Form 36), mood (Beck Depression Inventory-II), sleep quality (Pittsburgh Sleep Quality Index), and cognition (Cognitive Failures Questionnaire). A latent variable model revealed that although AD had a significant direct effect on quality of life, the indirect effect of sleep was significantly greater. Furthermore, although AD had no direct effect on cognitive functioning, the indirect effect of sleep was significant. The overall model showed a good fit (comparative fit index = 0.91, root mean square of approximation = 0.09, and standardized root mean square residual = 0.05). Our findings suggest that disrupted sleep, and not the disease per se, may induce poor quality of life, memory impairment, and affect dysregulation in patients with AD. We think that improving sleep architecture may improve cognitive, affective, and physical functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.