ArticleJournal of the American Chemical Society2015
Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Regio-, Stereo-, and Enantioselective C(spAngewandte Chemie (International ed. in English) · 2026Article
- Ligand-controlled sequential activation enables nickel-catalysed alkyl-alkynyl coupling.Nature communications · 2026Article
- Asymmetric synthesis of β-amino acid derivatives by stereocontrolled C(spNature communications · 2025Article
- Titanium-Mediated Organic Electrosynthesis.ACS catalysis · 2025Review
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- Kinetics and Mechanism of PPhJournal of the American Chemical Society · 2024Article
- Copper-Catalyzed α-Alkylation of Aryl Acetonitriles with Benzyl Alcohols.The Journal of organic chemistry · 2024Article
- Ni-catalyzed enantioconvergent deoxygenative reductive cross-coupling of unactivated alkyl alcohols and aryl bromides.Nature communications · 2024Article
- Enantioselective C(spAccounts of chemical research · 2024Article
- Nickel-catalyzed electrophiles-controlled enantioselective reductive arylative cyclization and enantiospecific reductive alkylative cyclization of 1,6-enynes.Nature communications · 2024Article
- Metal-Catalyzed Enantioconvergent Transformations.Chemical reviews · 2023Review
- Enantioselective Csp3-Csp3 formation by nickel-catalyzed enantioconvergent cross-electrophile alkyl-alkyl coupling of unactivated alkyl halides.Science advances · 2023Article
- Nickel/biimidazole-catalyzed electrochemical enantioselective reductive cross-coupling of aryl aziridines with aryl iodides.Nature communications · 2023Article
- Nickel-Catalyzed Enantioselective Electrochemical Reductive Cross-Coupling of Aryl Aziridines with Alkenyl Bromides.Journal of the American Chemical Society · 2023Article
- Boron Lewis Acid Catalysis Enables the Direct Cyanation of Benzyl Alcohols by Means of Isonitrile as Cyanide Source.Molecules (Basel, Switzerland) · 2023Article
- Ni/Photoredox-Catalyzed C(spJournal of the American Chemical Society · 2022Article
- Nickel-Catalyzed Enantioselective Reductive Alkyl-Carbamoylation of Internal Alkenes.Angewandte Chemie (International ed. in English) · 2022Article
- Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides.RSC advances · 2022Article
- Synergistic Catalyst-Mediator Pairings for Electroreductive Cross-Electrophile Coupling Reactions.ACS catalysis · 2022Article
- Tunable and Practical Homogeneous Organic Reductants for Cross-Electrophile Coupling.Journal of the American Chemical Society · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A Ni-catalyzed asymmetric reductive cross-coupling of heteroaryl iodides and α-chloronitriles has been developed. This method furnishes enantioenriched α,α-disubstituted nitriles from simple organohalide building blocks. The reaction tolerates a variety of heterocyclic coupling partners, including pyridines, pyrimidines, quinolines, thiophenes, and piperidines. The reaction proceeds under mild conditions at room temperature and precludes the need to pregenerate organometallic nucleophiles.
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