ArticleScientific reports2015
Streptomyces natalensis programmed cell death and morphological differentiation are dependent on oxidative stress.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
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- Metabolic adjustments in response to ATP spilling by the small DX protein in aFrontiers in cell and developmental biology · 2023Article
- Streptomyces coelicolor Vesicles: Many Molecules To Be Delivered.Applied and environmental microbiology · 2022Article
- A Proteomic Analysis Indicates That Oxidative Stress Is the Common Feature Triggering Antibiotic Production inFrontiers in microbiology · 2021Article
- The novel ECF56 SigG1-RsfG system modulates morphological differentiation and metal-ion homeostasis in Streptomyces tsukubaensis.Scientific reports · 2020Article
- The Onset of Tacrolimus Biosynthesis inAntibiotics (Basel, Switzerland) · 2020Article
- Negative Correlation between Lipid Content and Antibiotic Activity inAntibiotics (Basel, Switzerland) · 2020Article
- Expression of genes of the Pho regulon is altered in Streptomyces coelicolor.Scientific reports · 2020Article
- A Challenging View: Antibiotics Play a Role in the Regulation of the Energetic Metabolism of the Producing Bacteria.Antibiotics (Basel, Switzerland) · 2020Article
- The Inhibition of Antibiotic Production inFrontiers in microbiology · 2020Article
- Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures.Microbiology and molecular biology reviews : MMBR · 2018Review
- Complete Genome Sequence of the High-Natamycin-Producing StrainGenome announcements · 2018Article
- Production of Prodiginines Is Part of a Programmed Cell Death Process inFrontiers in microbiology · 2018Article
- Alpha-ketoglutarate protectsBiochemistry and biophysics reports · 2017Article
- Reactive oxygen species do not contribute to ObgE*-mediated programmed cell death.Scientific reports · 2016Article
- Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation.Applied microbiology and biotechnology · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomyces are aerobic Gram-positive bacteria characterized by a complex life cycle that includes hyphae differentiation and spore formation. Morphological differentiation is triggered by stressful conditions and takes place in a pro-oxidant environment, which sets the basis for an involvement of the oxidative stress response in this cellular process. Characterization of the phenotypic traits of Streptomyces natalensis ΔkatA1 (mono-functional catalase) and ΔcatR (Fur-like repressor of katA1 expression) strains in solid medium revealed that both mutants had an impaired morphological development process. The sub-lethal oxidative stress caused by the absence of KatA1 resulted in the formation of a highly proliferative and undifferentiated vegetative mycelium, whereas de-repression of CatR regulon, from which KatA1 is the only known representative, resulted in the formation of scarce aerial mycelium. Both mutant strains had the transcription of genes associated with aerial mycelium formation and biosynthesis of the hyphae hydrophobic layer down-regulated. The first round of the programmed cell death (PCD) was inhibited in both strains which caused the prevalence of the transient primary mycelium (MI) over secondary mycelium (MII). Our data shows that the first round of PCD and morphological differentiation in S. natalensis is dependent on oxidative stress in the right amount at the right time.
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