ArticleCarbohydrate polymers2015
Investigating triazine-based modification of hyaluronan using statistical designs.
Article in Carbohydrate polymers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Hyaluronic acid-based hydrogels: As an exosome delivery system in bone regeneration.Frontiers in pharmacology · 2023Review
- Coupling of kenaf Biochar and Magnetic BiFeOInternational journal of environmental research and public health · 2020Article
- Depletion of Cr(VI) from aqueous solution by heat dried biomass of a newly isolated fungus Arthrinium malaysianum: A mechanistic approach.Scientific reports · 2017Article
- Article
- Statistical Analysis of Main and Interaction Effects on Cu(II) and Cr(VI) Decontamination by Nitrogen-Doped Magnetic Graphene Oxide.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Hyaluronan (HA) and its derivatives have been extensively researched for many biomedical applications. To precisely tailor the property of HA by derivatizing it to a pre-determined extent is challenging, yet critical. In this paper, we used 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and N-methylmorpholine (NMM) to derivatize HA via a triazine-based coupling reaction. Using a fractional factorial (FF) design, we observed that water content in the solvent, and molar ratios of CDMT and NaHCO3 to the carboxylate were the significant factors controlling the derivatization. We investigated how the effect of each factor changes as reaction conditions change. Moreover, by altering the amount of CDMT and NaHCO3, we developed a cubic regression model for precise control of the extent of derivatization using a response surface methodology (RSM) with a D-optimal design. No spurious peaks were detected by (1)H NMR spectrum and only 10% decrease of molecular weight of the derivatized HA was determined by GPC. The HA with 6% modification was relatively biocompatible up to 15 mg/mL.
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Registered trials
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