Evidence map›Paper›PMID 26256246›Full record

ArticleTrends in biochemical sciences2015

Cytosolic BMAL1 moonlights as a translation factor.

Alicia K Michael, Hande Asimgil, Carrie L Partch

Open access · greenAbstract readComment
In one paragraph

Article in Trends in biochemical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Circadian rhythms and renal pathophysiology.The Journal of clinical investigation · 2022
    Review
  7. Article
  8. Molecular Interactions between Pathogens and the Circadian Clock.International journal of molecular sciences · 2019
    Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alicia K MichaelDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Hande AsimgilDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Carrie L PartchDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. Electronic address: cpartch@ucsc.edu.
University of California, Santa Cruz · US

Funding

Exploring the structural basis for 24-hour timekeeping in mammalsR01GM107069 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI PARTCH, CARRIE L · 2013 to 2020
$3.2M
Disruption of the circadian clock by a cancer/testis antigenF31CA189660 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MICHAEL, ALICIA · 2014 to 2016
$112k
NCI NIH HHS F31 CA189660NIGMS NIH HHS R01 GM107069
6 · The paper itself

Abstract

It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling.

Indexed as

Circadian ClocksAnimalsARNTL Transcription FactorsRibosomal Protein S6 Kinases, 90-kDaARNTL Transcription FactorsRibosomal Protein S6 Kinases, 90-kDa

Identifiers

PMID26256246
PMCPMC4578652
OpenAlexW1626313345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.