ArticleDevelopmental cell2015
Axud1 Integrates Wnt Signaling and Transcriptional Inputs to Drive Neural Crest Formation.
Article in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- The lipid raft-linker gene Raftlin-2 is expressed in migrating neural crest cells.Differentiation; research in biological diversity · 2026Article
- Integrated Single-cell Analysis Uncovers Regulatory Logic of Cranial Ectoderm Development.bioRxiv : the preprint server for biology · 2025Article
- Hominoid-specific transposable elements reshaped neural crest migration in craniofacial development.Molecular systems biology · 2025Article
- A modular enhancer mediates SCRT2 repression of ISLET1 in the spinal cord.Developmental biology · 2025Article
- Determination of trunk neural crest cell fate and susceptibility to splicing perturbation by the DLC1-SF3B1-PHF5A splicing complex.Nature communications · 2025Article
- TGF-β signaling controls neural crest developmental plasticity via SMAD2/3.Developmental cell · 2025Article
- Gag proteins encoded by endogenous retroviruses are required for zebrafish development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos.Developmental biology · 2025Article
- Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential.Nature communications · 2023Article
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- Integrated analyses reveal evolutionarily conserved and specific injury response genes in dorsal root ganglion.Scientific data · 2022Article
- RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification.eLife · 2022Article
- Time to go: neural crest cell epithelial-to-mesenchymal transition.Development (Cambridge, England) · 2022Review
- The connectome of neural crest enhancers reveals regulatory features of signaling systems.Developmental cell · 2021Article
- A single-plasmid approach for genome editing coupled with long-term lineage analysis in chick embryos.Development (Cambridge, England) · 2021Article
- Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model.Nucleic acids research · 2021Article
- Neural crest multipotency and specification: power and limits of single cell transcriptomic approaches.Faculty reviews · 2021Review
- On the road again: Establishment and maintenance of stemness in the neural crest from embryo to adulthood.Stem cells (Dayton, Ohio) · 2021Review
- Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT.Frontiers in physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neural crest cells are induced at the neural plate border by the combined action of transcription factors and signaling molecules. Here, we show that Axud1, a downstream effector of Wnt signaling, represents a critical missing link that integrates signaling and transcriptional cues to mediate neural crest formation. Axud1 is a transcription factor expressed in neural crest progenitors in a Wnt1/β-catenin-dependent manner. Axud1 loss leads to downregulation of multiple genes involved in neural crest specification, similar to the effects of Wnt1 knockdown. Importantly, Axud1 is sufficient to rescue neural crest formation after disruption of Wnt signaling. Furthermore, it physically interacts with neural plate border genes Pax7 and Msx1 in vivo to directly activate transcription of stem cell factor FoxD3, initiating the neural crest program. Thus, Axud1 integrates Wnt signaling with transcriptional inputs to endow the neural crest with its unique molecular signature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.