Evidence map›Paper›PMID 26256100›Full record

ArticleThe Laryngoscope2016

The effects of treadmill running on aging laryngeal muscle structure.

Heidi Kletzien, John A Russell, Nadine P Connor

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04362228 (The Effects of Whole-body Exercise to Improve Swallowing Function in Older Adults With Dementia), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04362228 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effects of Whole-body Exercise to Improve Swallowing Function in Older Adults With Dementia

TypeinterventionalSponsorMcMaster UniversityRan2021 to 2022Enrolled9ConditionsOld Age, Dementia, Swallowing Disorder, CoughArmsWhole-body exercise
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Effects of Vocal Training on Thyroarytenoid Muscle Neuromuscular Junctions and Myofibers in Young and Older Rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  7. Laryngeal muscle biology in theJournal of applied physiology (Bethesda, Md. : 1985) · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Heidi KletzienDepartment of Surgery, Otolaryngology-Head and Neck Surgery, University of Wisconsin, Madison, Wisconsin, U.S.A.
John A RussellDepartment of Surgery, Otolaryngology-Head and Neck Surgery, University of Wisconsin, Madison, Wisconsin, U.S.A.
Nadine P ConnorDepartment of Surgery, Otolaryngology-Head and Neck Surgery, University of Wisconsin, Madison, Wisconsin, U.S.A.
University of Wisconsin–Madison · US

Funding

University of Wisconsin Voice Research Training Program (T32)T32DC009401 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2009 to 2026
$6.3M
Lingual and Laryngeal Muscle PlasticityR01DC008149 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI CONNOR, NADINE P · 2007 to 2017
$4.5M
Exercise as a Treatment for Tongue Weakness in Aged RatsR01DC005935 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI CONNOR, NADINE P · 2003 to 2014
$3.3M
NIDCD NIH HHS R01 DC005935NIDCD NIH HHS R01DC005935NIDCD NIH HHS R01 DC008149NIDCD NIH HHS R01DC008149NIDCD NIH HHS T32 DC009401NIDCD NIH HHS T32DC009401
6 · The paper itself

Abstract

objectives/hypothesisAge-related changes in laryngeal muscle structure and function may contribute to deficits in voice and swallowing observed in elderly people. We hypothesized that treadmill running, an exercise that increases respiratory drive to upper airway muscles, would induce changes in thyroarytenoid muscle myosin heavy chain (MHC) isoforms that are consistent with a fast-to-slow transformation in muscle fiber type. STUDY

designRandomized parallel group controlled trial.

methodsFifteen young adult and 14 old Fischer 344/Brown Norway rats received either treadmill running or no exercise (5 days/week/8 weeks). Myosin heavy chain isoform composition in the thyroarytenoid muscle was examined at the end of 8 weeks.

resultsSignificant age and treatment effects were found. The young adult group had the greatest proportion of superfast-contracting MHCIIL isoform. The treadmill running group had the lowest proportion of MHCIIL and the greatest proportion of MHCIIx isoforms.

conclusionThyroarytenoid muscle structure was affected both by age and treadmill running in a fast-to-slow transition that is characteristic of exercise manipulations in other skeletal muscles. LEVEL OF EVIDENCE: NA. Laryngoscope, 126:672-677, 2016.

Indexed as

AdultAgingAnalysis of VarianceAnimalsExercise TestHumansLaryngeal MusclesMaleModels, AnimalMuscle FatiguePhysical Conditioning, AnimalRandom AllocationRatsRats, Inbred F344RunningYoung Adultagingexerciselarynxrespirationswallowingswallowing disordersthyroarytenoidVoicevoice disorders

Identifiers

PMID26256100
PMCPMC4746111
OpenAlexW2105135919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.