ArticleScientific reports2015
Evaluation of genetic susceptibility of common variants in CACNA1D with schizophrenia in Han Chinese.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- CACNA1D-Related Channelopathies: From Hypertension to Autism.Handbook of experimental pharmacology · 2023Review
- Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours?Molecular neurobiology · 2021Article
- Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy.Scientific reports · 2019Article
- Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.International journal of molecular sciences · 2019Review
- Evaluation of genetic susceptibility between systemic lupus erythematosus and GRB2 gene.Scientific reports · 2019Article
- IRAK2 and TLR10 confer risk of Hashimoto's disease: a genetic association study based on the Han Chinese population.Journal of human genetics · 2019Article
- Relationship of common variants in Interleukin 33 gene with susceptibility and prognosis of osteosarcoma in Han Chinese population.Journal of Cancer · 2019Article
- Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator.Scientific reports · 2018Article
- Relationship of common variants in VEGFA gene with osteonecrosis of the femoral head: A Han Chinese population based association study.Scientific reports · 2018Article
- Genetic susceptibility of postmenopausal osteoporosis on sulfide quinone reductase-like gene.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- A common polymorphism of COMT was associated with symptomatic lumbar disc herniation based on a large sample with Chinese Han ancestry.Scientific reports · 2018Article
- Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population.Scientific reports · 2018Article
- MDM4 contributes to the increased risk of glioma susceptibility in Han Chinese population.Scientific reports · 2018Article
- Common variants in the GNL3 contribute to the increasing risk of knee osteoarthritis in Han Chinese population.Scientific reports · 2018Article
- Association of BET1L and TNRC6B with uterine leiomyoma risk and its relevant clinical features in Han Chinese population.Scientific reports · 2018Article
- Genetic polymorphisms of NOS2 and predisposition to fracture non-union: A case control study based on Han Chinese population.PloS one · 2018Article
- Evaluation of the association ofOncotarget · 2017Article
- Genetic association study identified a 20 kb regulatory element in WLS associated with osteoporosis and bone mineral density in Han Chinese.Scientific reports · 2017Article
- From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Polymorphisms of RAD51B are associated with rheumatoid arthritis and erosion in rheumatoid arthritis patients.Scientific reports · 2017Article
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Authors and funding
8 authors.
Funding
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Abstract
The heritability of schizophrenia (SCZ) has been estimated to be as high as 80%, suggesting that genetic factors may play an important role in the etiology of SCZ. Cav1.2 encoded by CACNA1C and Cav1.3 encoded by CACNA1D are dominant calcium channel-forming subunits of L-type Voltage-dependent Ca(2+) channels, expressed in many types of neurons. The CACNA1C has been consistently found to be a risk gene for SCZ, but it is unknown for CACNA1D. To investigate the association of CACNA1D with SCZ, we designed a two-stage case-control study, including a testing set with 1117 cases and 1815 controls and a validation set with 1430 cases and 4295 controls in Han Chinese. A total of selected 97 tag single nucleotide polymorphisms (SNPs) in CACNA1D were genotyped, and single-SNP association, imputation analysis and gender-specific association analyses were performed in the two independent datasets. None was found to associate with SCZ. Further genotype and haplotype association analyses indicated a similar pattern in the two-stage study. Our findings suggested CACNA1D might not be a risk gene for SCZ in Han Chinese population, which add to the current state of knowledge regarding the susceptibility of CACNA1D to SCZ.
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