ArticleScientific reports2015
Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Quality Assurance Strategies for Brain State Characterization by MEMRI.bioRxiv : the preprint server for biology · 2026Article
- Developmental changes in brain activity of heterozygousFrontiers in neurology · 2023Article
- Excess intracellular ATP causes neuropathic pain following spinal cord injury.Cellular and molecular life sciences : CMLS · 2022Article
- lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p.International journal of molecular medicine · 2021Article
- Manganese Dynamics in Mouse Brain After Systemic MnClFrontiers in neural circuits · 2021Article
- Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases.Frontiers in neurology · 2020Review
- Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer's disease.Scientific reports · 2019Article
- Store-Operated Calcium Channels Are Involved in Spontaneous Slow Calcium Oscillations in Striatal Neurons.Frontiers in cellular neuroscience · 2019Article
- Primary Role of the Amygdala in Spontaneous Inflammatory Pain- Associated Activation of Pain Networks - A Chemogenetic Manganese-Enhanced MRI Approach.Frontiers in neural circuits · 2019Article
- Visualization of Brain Activity in a Neuropathic Pain Model Using Quantitative Activity-Dependent Manganese Magnetic Resonance Imaging.Frontiers in neural circuits · 2019Article
- Manganese Enhanced MRI for Use in Studying Neurodegenerative Diseases.Frontiers in neural circuits · 2018Review
- Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies.Behavioural neurology · 2018Article
- Mapping of pain circuitry in early post-natal development using manganese-enhanced MRI in rats.Neuroscience · 2017Article
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Authors and funding
9 authors.
Funding
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Abstract
We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson's disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.
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