Evidence map›Paper›PMID 26255627›Full record

ArticleOncotarget2015

Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence.

Ping Niu, Aibek Smagul, Lu Wang, Aiman Sadvakas, Ying Sha, Laura M Pérez, Aliya Nussupbekova, Aday Amirbekov, Akan A Akanov, Beatriz G Gálvez and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Role of Adipose-Derived Mesenchymal Stem Cells in Bone Regeneration.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Extracellular Vesicles in Skin Wound Healing.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ping NiuDepartment of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, China.
Aibek SmagulS.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Lu WangSchool of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
Aiman SadvakasS.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Ying ShaSchool of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
Laura M PérezCardiac Development and Repair Department, National Center for Cardiovascular Research (CNIC), Madrid, Spain.
Aliya NussupbekovaS.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Aday AmirbekovS.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Akan A AkanovS.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Beatriz G GálvezCardiac Development and Repair Department, National Center for Cardiovascular Research (CNIC), Madrid, Spain.
I King JordanSchool of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
Victoria V LunyakAelan Cell Technologies, Inc, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is a double-edged sword with both detrimental and beneficial consequences. Understanding of the mechanisms of crosstalk between the inflammatory milieu and human adult mesenchymal stem cells is an important basis for clinical efforts. Here, we investigate changes in the transcriptional response of human adipose-derived stem cells to physiologically relevant levels of IL-2 (IL-2 priming) upon replicative senescence. Our data suggest that replicative senescence might dramatically impede human mesenchymal stem cell (MSC) function via global transcriptional deregulation in response to IL-2. We uncovered a novel senescence-associated transcriptional signature in human adipose-derived MSCs hADSCs after exposure to pro-inflammatory environment: significant enhancement of the expression of the genes encoding potent growth factors and cytokines with anti-inflammatory and migration-promoting properties, as well as genes encoding angiogenic and anti-apoptotic promoting factors, all of which could participate in the establishment of a unique microenvironment. We observed transcriptional up-regulation of critical components of the nitric oxide synthase pathway (iNOS) in hADSCs upon replicative senescence suggesting, that senescent stem cells can acquire metastasis-promoting properties via stem cell-mediated immunosuppression. Our study highlights the importance of age as a factor when designing cell-based or pharmacological therapies for older patients and predicts measurable biomarkers characteristic of an environment that is conducive to cancer cells invasiveness and metastasis.

Indexed as

Cellular SenescenceOligonucleotide Array Sequence AnalysisAdipose TissueAdultCell MovementCell ProliferationCells, CulturedCluster AnalysisFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Regulatory NetworksHumansInterleukin-2Mesenchymal Stem CellsMiddle AgedInterleukin-2Recombinant ProteinsagingcancerGerotargetIL-2immunomodulationmesenchymal stem cells

Identifiers

PMID26255627
PMCPMC4627227

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.