ArticleInternational journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition2014
Folic Acid Fortification and Women's Folate Levels in Selected Communities in Brazil - A First Look.
Article in International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03421483 (Factors Affecting Colonic Folate Absorption and Metabolism in Humans), which is not on this map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Factors Affecting Colonic Folate Absorption and Metabolism in Humans
Who cites it
6 citing papers in PubMed.
- Biological, dietetic and pharmacological properties of vitamin BNPJ science of food · 2025Review
- Excess prenatal folic acid supplementation alters cortical DNA methylation and gene expression networks.Frontiers in nutrition · 2025Article
- Challenges in rural maternal health: how received public services and policy awareness affect health knowledge and practices.Frontiers in public health · 2024Article
- Maternal Folic Acid Supplementation during Pregnancy and Childhood Allergic Disease Outcomes: A Question of Timing?Nutrients · 2017Review
- Article
- Prevalence of low folate deficiency after wheat flour supplementation - should we still measure serum folate?Hematology, transfusion and cell therapyArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundSeveral countries have implemented mandatory folic acid fortification of wheat flour and selected grain products to increase the folate intake of reproductive-aged women. Brazil implemented a folic acid fortification program in 2004. No previous studies have examined folate differences among Brazilian women following the mandate.
objectiveWe evaluate differences in serum and red blood cell (RBC) folate concentrations between two samples of women of childbearing age from selective communities in Brazil, one tested before (N = 116) and the other after the mandate (N = 240).
methodsWe compared the baseline folate levels of women enrolled in a prevention study shortly before the fortification mandate was implemented, to baseline levels of women from the same communities enrolled in the same study shortly after fortification began. The participants were women enrolled in a folate supplementation clinical trial, at a hospital specializing in treating craniofacial anomalies in the city of Bauru from January 29, 2004 to April 27, 2005. We only compared baseline folate levels before the women received oral cleft prevention program (OCPP) folic acid supplements.
resultsWomen enrolled after the fortification mandate had higher means of serum folate (20.3 versus 11.2 nmol/L; p < 0.001) and RBC folate (368.3 versus 177.6 nmol/L; p < 0.001) than women enrolled before the mandate. Differences in folate levels between the two groups remained after adjusting for several co-variables.
conclusionsThe results suggest that serum and RBC folate levels among women of childbearing age increased after implementing the folic acid fortification mandate in Brazil.
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Registered trials
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