Evidence map›Paper›PMID 26255259›Full record

ArticleInternational journal of colorectal disease2016

Layer-oriented total pelvic exenteration for locally advanced primary colorectal cancer.

Keiji Koda, Kiyohiko Shuto, Kenichi Matsuo, Chihiro Kosugi, Mikito Mori, Atsushi Hirano, Yukihiko Hiroshima, Kuniya Tanaka

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Keiji KodaDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara City, Chiba, 2990111, Japan. k-koda@med.teikyo-u.ac.jp.
Kiyohiko ShutoDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara City, Chiba, 2990111, Japan.
Kenichi MatsuoDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara City, Chiba, 2990111, Japan.
Chihiro KosugiDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara City, Chiba, 2990111, Japan.
Mikito MoriDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara City, Chiba, 2990111, Japan.
Atsushi HiranoDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara City, Chiba, 2990111, Japan.
Yukihiko HiroshimaDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara City, Chiba, 2990111, Japan.
Kuniya TanakaDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara City, Chiba, 2990111, Japan.
Teikyo University Chiba Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe clinical outcomes of patients who have undergone total pelvic exenteration (TPE) for locally advanced primary colorectal cancer have not been satisfactory. For the last 13 years, we have performed layer-oriented, en bloc resection of tumor for which TPE is indicated, in the hope of improving postoperative outcomes. The clinical outcomes of these cases were retrospectively analyzed.

methodsA total of 54 patients who underwent TPE from 1986 to 2013 were retrospectively analyzed. Since 2002, a layer-oriented removal for clinical T4 colorectal cancer, as in T3 or less invasive tumors removed by total mesorectal excision, was applied to 23 cases for which TPE was indicated. Postoperative mortality, morbidity, overall survival (OS), and disease-free survival (DFS) were evaluated.

resultsOn univariate analysis, good postoperative OS and DFS were associated with the layer-oriented operative maneuver, blood loss less than 2000 mL, negative nodal metastasis, and no preoperative radiation therapy. Male sex was the marginal determinant correlated with good OS and DFS. Depth of invasion to T3 was the marginal determinant correlated with good DFS. On multivariate analysis using the 4 factors identified on univariate analyses, the layer-oriented operative procedure was a significant determinant for both good OS and DFS, together with negative nodal metastases. Postoperative mortality and morbidity in the layer-oriented excision were acceptable.

conclusionFor primary colorectal cancers for which TPE is indicated, layer-oriented excision was a safe and effective procedure, and it may be recommended as one of the standard surgical approaches in TPE.

Indexed as

AdultAgedAged, 80 and overColorectal NeoplasmsDisease-Free SurvivalFemaleHospital MortalityHumansIntraoperative CareMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalNeoplasm StagingPelvic ExenterationPelvisLayer-oriented operationPrognosisPrognostic factorSurgical techniqueSurvivalTotal pelvic exenteration

Identifiers

PMID26255259
OpenAlexW2107701150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.