Evidence map›Paper›PMID 26255045›Full record

Trial reportGastroenterology2015

Incidence and mortality of colorectal cancer in individuals with a family history of colorectal cancer.

Robert E Schoen, Anthony Razzak, Kelly J Yu, Sonja I Berndt, Kevin Firl, Thomas L Riley, Paul F Pinsky

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00002540 (Prostate, Lung, Colorectal, and Ovarian), which is not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00002540 naactive not recruitingnot on this map

Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial

TypeinterventionalSponsorNational Cancer Institute (NCI)Ran1993 to 2027Enrolled76,685ConditionsProstate CarcinomaArmsLaboratory Biomarker Analysis, Medical Examination Assessment, Screening Questionnaire Administration
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Robert E SchoenDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: rschoen@pitt.edu.
Anthony RazzakDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania.
Kelly J YuDivision of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Kevin FirlDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Thomas L RileyInformation Management Services, Inc., Rockville, Maryland.
Paul F PinskyDivision of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
National Cancer Institute · USUniversity of Pittsburgh · USDivision of Cancer Epidemiology and GeneticsInformation Management Services · US

Funding

Refinement and Discovery of Nuclear Matrix Protein Markers for Colorectal CancerU01CA152753 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KINZLER, KENNETH W., SCHOEN, ROBERT E. · 2010 to 2021
$6.8M
PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCERN01CN025511 · CN · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WEISSFELD, JOEL L · 1992 to 2000
$1.2M
NCI NIH HHS N01 CN025511NCI NIH HHS N01-CN-25511NCI NIH HHS U01 CA152753
6 · The paper itself

Abstract

BACKGROUND &

aimsLittle is known about the change in risk conferred by family history of colorectal cancer (CRC) as a person ages. We evaluated the effect of family history on CRC incidence and mortality after 55 years of age, when the risk of early onset cancer had passed.

methodsWe collected data from participants in the randomized, controlled Prostate, Lung, Colorectal and Ovarian cancer screening trial of flexible sigmoidoscopy versus usual care (55-74 years old, no history of CRC), performed at 10 US centers from 1993 to 2001. A detailed family history of colorectal cancer was obtained at enrollment, and subjects were followed for CRC incidence and mortality for up to 13 years.

resultsAmong 144,768 participants, 14,961 subjects (10.3%) reported a family of CRC. Of 2090 incident cases, 273 cases (13.1%) had a family history of CRC; among 538 deaths from CRC, 71 (13.2%) had a family history of CRC. Overall, family history of CRC was associated with an increased risk of CRC incidence (hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.10-1.50; P<.0001) and increased mortality (HR, 1.31; 95% CI, 1.02-1.69; P = .03). Subjects with 1 first degree relative (FDR) with CRC (n = 238; HR, 1.23; 95% CI, 1.07-1.42) or ≥2 FDRs with CRC (n = 35; HR, 2.04; 95% CI, 1.44-2.86) were at increased risk for incident CRC. However, among individuals with 1 FDR with CRC, there were no differences in risk based on age at diagnosis in the FDR (for FDR <60 years of age: HR, 1.27; 95% CI, 0.97-1.63; for FDR 60-70 years of age: HR, 1.33; 95% CI, 1.06-1.62; for FDR >70 years of age: HR, 1.14; 95% CI, 0.93-1.45; P trend = .59).

conclusionsAfter 55 years of age, subjects with 1 FDR with CRC had only a modest increase in risk for CRC incidence and death; age of onset in the FDR was not significantly associated with risk. Individuals with ≥2 FDRs with CRC had continued increased risk in older age. Guidelines and clinical practice for subjects with a family history of CRC should be modified to align CRC testing to risk. ClinicalTrials.gov number, NCT00002540.

Indexed as

ColonoscopyFamilySigmoidoscopyAgedAge FactorsColorectal NeoplasmsEarly Detection of CancerFemaleFollow-Up StudiesHumansIncidenceMaleMass ScreeningMiddle AgedRisk FactorsAdenomatous PolypsColon CancerGenetic Risk FactorsScreening

Identifiers

PMID26255045
PMCPMC4628587
OpenAlexW2171107612

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.