Trial reportThe Journal of pediatrics2015
Antenatal Magnesium and Cerebral Palsy in Preterm Infants.
Trial report in The Journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00014989 (Randomized Clinical Trial of the Beneficial Effects of Antenatal Magnesium Sulfate), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Clinical Trial of the Beneficial Effects of Antenatal Magnesium Sulfate (BEAM)
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.The Cochrane database of systematic reviews · 2026Pooled it
- Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.The Cochrane database of systematic reviews · 2024Pooled it
- Prenatal Magnesium Sulfate and Functional Connectivity in Offspring at Term-Equivalent Age.JAMA network open · 2024Trial
- Exendin-4 improves neurodevelopmental outcome after neonatal germinal matrix hemorrhage.Cell death & disease · 2026Article
- Intraventricular hemorrhage profile in very low birth weight preterm infants (< 1000 g and ≥ 1000 g) at a tertiary center in São Paulo State over a decade.Clinics (Sao Paulo, Brazil) · 2026Article
- A follow up on the feasibility after national implementation of magnesium sulfate for neuroprotection prior to preterm birth.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice.Frontiers in neurology · 2023Review
- The effect of antenatal magnesium sulfate on intraventricular hemorrhage in premature infants: a systematic review and meta-analysis.Obstetrics & gynecology science · 2020Article
- A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups.Frontiers in cellular neuroscience · 2020Article
- Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Fetal Neuroprotection by Magnesium Sulfate: From Translational Research to Clinical Application.Frontiers in neurology · 2018Review
- In Premature Newborns Intraventricular Hemorrhage Causes Cerebral Vasospasm and Associated NeurodisabilityFrontiers in neurology · 2017Article
- Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns.The Journal of pediatrics · 2016Article
- Antenatal Betamethasone: A Prolonged Time Interval from Administration to Delivery Is Associated with an Increased Incidence of Severe Intraventricular Hemorrhage in Infants Born before 28 Weeks Gestation.The Journal of pediatrics · 2016Article
- What we learned about the role of antenatal magnesium sulfate for the prevention of cerebral palsy.Seminars in perinatology · 2016Review
- Neonatal Magnesium Levels Between 24 and 48 Hours of Life and Outcomes for Epilepsy and Motor Impairment in Premature Infants.Pediatric neurology · 2016Article
- Perinatal neuroprotection update.F1000Research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 20 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the relationship of maternal antenatal magnesium sulfate (MgSO4) with neonatal cranial ultrasound abnormalities and cerebral palsy (CP). STUDY
designIn a randomized trial of MgSO4 or placebo in women at high risk of preterm delivery, up to 3 cranial ultrasounds were obtained in the neonatal period. Images were reviewed by at least 2 pediatric radiologists masked to treatment and other clinical conditions. Diagnoses were predefined for intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly. CP was diagnosed at 2 years of age by standardized neurologic examination.
resultsIntraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly were all strongly associated with an increased risk of CP. MgSO4 administration did not affect the risk of cranial ultrasound abnormality observed at 35 weeks postmenstrual age or later. However, for the 82% of infants born at <32 weeks gestation, MgSO4 was associated with a reduction in risk of echolucency or echodensity. The reduction in risk for echolucency explained 21% of the effect of MgSO4 on CP (P = .04), and for echodensity explained 20% of the effect (P = .02).
conclusionsMgSO4 given prior to preterm delivery was associated with decreased risk of developing echodensities and echolucencies at <32 weeks gestation. However, this effect can only partially explain the effect of MgSO4 on CP at 2 years of age.
trial registrationClinicalTrials.gov: NCT00014989.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.