Evidence map›Paper›PMID 26254746›Full record

ArticleBrain imaging and behavior2016

Canonical feature selection for joint regression and multi-class identification in Alzheimer's disease diagnosis.

Xiaofeng Zhu, Heung-Il Suk, Seong-Whan Lee, Dinggang Shen

Open access · greenAbstract read
In one paragraph

Article in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. A Novel Hybrid Ordinal Learning Model with Health Care Application.IEEE transactions on automation science and engineering : a publication of the IEEE Robotics and Automation Society · 2025
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  17. Multi-Layer Multi-View Classification for Alzheimer's Disease Diagnosis.Proceedings of the ... AAAI Conference on Artificial Intelligence. AAAI Conference on Artificial Intelligence · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Xiaofeng ZhuDepartment of Radiology and BRIC, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Heung-Il SukDepartment of Brain and Cognitive Engineering, Korea University, Seongbuk-gu, Republic of Korea.
Seong-Whan LeeDepartment of Brain and Cognitive Engineering, Korea University, Seongbuk-gu, Republic of Korea.
Dinggang ShenDepartment of Radiology and BRIC, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dgshen@med.unc.edu.
Korea University · KRUniversity of North Carolina at Chapel Hill · US

Funding

Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Development of Robust Brain Measurement Tools Informed by Ultrahigh Field 7T MRIR01EB006733 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2008 to 2020
$4.5M
Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
Infant Brain Measurement and Super-Resolution Atlas ConstructionR01MH100217 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2013 to 2016
$2.3M
Assessing Large-scale Brain Connectivities in Mild Cognitive ImpairmentR01AG042599 · NIA · UNIVERSITY OF GEORGIA · PI LIU, TIANMING · 2013 to 2017
$1.4M
Fast, Robust Analysis of Large Population DataR01EB009634 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2011 to 2014
$1.3M
NIA NIH HHS R01 AG041721NIA NIH HHS R01 AG042599NIBIB NIH HHS R01 EB006733NIBIB NIH HHS R01 EB008374NIBIB NIH HHS R01 EB009634NIMH NIH HHS R01 MH100217
6 · The paper itself

Abstract

Fusing information from different imaging modalities is crucial for more accurate identification of the brain state because imaging data of different modalities can provide complementary perspectives on the complex nature of brain disorders. However, most existing fusion methods often extract features independently from each modality, and then simply concatenate them into a long vector for classification, without appropriate consideration of the correlation among modalities. In this paper, we propose a novel method to transform the original features from different modalities to a common space, where the transformed features become comparable and easy to find their relation, by canonical correlation analysis. We then perform the sparse multi-task learning for discriminative feature selection by using the canonical features as regressors and penalizing a loss function with a canonical regularizer. In our experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, we use Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) images to jointly predict clinical scores of Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and Mini-Mental State Examination (MMSE) and also identify multi-class disease status for Alzheimer's disease diagnosis. The experimental results showed that the proposed canonical feature selection method helped enhance the performance of both clinical score prediction and disease status identification, outperforming the state-of-the-art methods.

Indexed as

Magnetic Resonance ImagingPositron-Emission TomographyAgedAged, 80 and overAlgorithmsAlzheimer DiseaseBrainDatasets as TopicFemaleHumansMaleMental Status ScheduleMiddle AgedNeuropsychological TestsRegression AnalysisAlzheimer’s diseaseCanonical correlation analysisFeature selectionMild cognitive impairment conversionMulti-class classification

Identifiers

PMID26254746
PMCPMC4747862
OpenAlexW2123623728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.