Evidence map›Paper›PMID 26254587›Full record

SynthesisNeuroImage2015

Neural networks involved in adolescent reward processing: An activation likelihood estimation meta-analysis of functional neuroimaging studies.

Merav H Silverman, Kelly Jedd, Monica Luciana

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 13 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 13 syntheses or guidelines pooled it, 281 citations in OpenAlex.

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  14. Trial
  15. Neural Correlates of Reward Processing in Depressed and Healthy Preschool-Age Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2016
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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Merav H SilvermanDepartment of Psychology, University of Minnesota, Twin Cities, 75 East River Parkway, Minneapolis, MN 55455, USA. Electronic address: silve369@umn.edu.
Kelly JeddInstitute of Child Development, University of Minnesota, Twin Cities, 51 East River Parkway, Minneapolis, MN 55455, USA.
Monica LucianaDepartment of Psychology, University of Minnesota, Twin Cities, 75 East River Parkway, Minneapolis, MN 55455, USA; Center for Neurobehavioral Development, University of Minnesota, Twin Cities, 717 Delaware, Minneapolis, MN 55455, USA.
University of Minnesota · US

Funding

INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32MH015755 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Megan R Gunnar · 1985 to 2026
$5.9M
Disrupted development of neural connections by alcohol initiation in adolescenceR01AA020033 · NIAAA · UNIVERSITY OF MINNESOTA · PI LUCIANA, MONICA · 2011 to 2015
$2.7M
NIAAA NIH HHS R01 AA020033NIMH NIH HHS T32 MH015755
6 · The paper itself

Abstract

Behavioral responses to, and the neural processing of, rewards change dramatically during adolescence and may contribute to observed increases in risk-taking during this developmental period. Functional MRI (fMRI) studies suggest differences between adolescents and adults in neural activation during reward processing, but findings are contradictory, and effects have been found in non-predicted directions. The current study uses an activation likelihood estimation (ALE) approach for quantitative meta-analysis of functional neuroimaging studies to: (1) confirm the network of brain regions involved in adolescents' reward processing, (2) identify regions involved in specific stages (anticipation, outcome) and valence (positive, negative) of reward processing, and (3) identify differences in activation likelihood between adolescent and adult reward-related brain activation. Results reveal a subcortical network of brain regions involved in adolescent reward processing similar to that found in adults with major hubs including the ventral and dorsal striatum, insula, and posterior cingulate cortex (PCC). Contrast analyses find that adolescents exhibit greater likelihood of activation in the insula while processing anticipation relative to outcome and greater likelihood of activation in the putamen and amygdala during outcome relative to anticipation. While processing positive compared to negative valence, adolescents show increased likelihood for activation in the posterior cingulate cortex (PCC) and ventral striatum. Contrasting adolescent reward processing with the existing ALE of adult reward processing reveals increased likelihood for activation in limbic, frontolimbic, and striatal regions in adolescents compared with adults. Unlike adolescents, adults also activate executive control regions of the frontal and parietal lobes. These findings support hypothesized elevations in motivated activity during adolescence.

Indexed as

RewardAdolescentAdultBrainBrain MappingChildFemaleHumansLikelihood FunctionsMagnetic Resonance ImagingMaleNerve NetYoung Adult

Identifiers

PMID26254587
PMCPMC4618189
OpenAlexW1085529922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.