ArticleDiabetologia2015
Elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation during diet-induced insulin resistance in dogs.
Article in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Weight loss in MASLD restores the balance of liver fatty acid sources.The Journal of clinical investigation · 2025Trial
- A pilot study testing a continuous glucose monitoring sensor in lean growing pigs fed contrasting diets, to document nocturnal and diurnal glycemic excursions as well as their relationships.Veterinary and animal science · 2026Review
- Independent and interactive associations of heart rate and obesity with type 2 diabetes mellites: A population-based study.Journal of diabetes · 2024Article
- Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes.American journal of physiology. Endocrinology and metabolism · 2023Article
- Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance.Diabetologia · 2023Article
- Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience.Frontiers in veterinary science · 2022Article
- Hyperinsulinemic Compensation for Insulin Resistance Occurs Independent of Elevated Glycemia in Male Dogs.Endocrinology · 2021Article
- Impact of sleep deprivation and high-fat feeding on insulin sensitivity and beta cell function in dogs.Diabetologia · 2020Article
- Origins and History of the Minimal Model of Glucose Regulation.Frontiers in endocrinology · 2020Article
- Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes.Diabetes · 2019Article
- Two nights of recovery sleep restores the dynamic lipemic response, but not the reduction of insulin sensitivity, induced by five nights of sleep restriction.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Associations Among Dietary Fat Oxidation Responses to Overfeeding and Weight Gain in Obesity-Prone and Resistant Adults.Obesity (Silver Spring, Md.) · 2018Article
- Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice.Diabetologia · 2017Article
- Ability to adjust nocturnal fat oxidation in response to overfeeding predicts 5-year weight gain in adults.Obesity (Silver Spring, Md.) · 2017Article
- Article
- Initial hyperinsulinemia and subsequent β-cell dysfunction is associated with elevated palmitate levels.Pediatric research · 2016Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisA normal consequence of increased energy intake and insulin resistance is compensatory hyperinsulinaemia through increased insulin secretion and/or reduced insulin clearance. Failure of compensatory mechanisms plays a central role in the pathogenesis of type 2 diabetes mellitus; consequently, it is critical to identify in vivo signal(s) involved in hyperinsulinaemic compensation. We have previously reported that high-fat feeding leads to an increase in nocturnal NEFA concentration. We therefore designed this study to test the hypothesis that elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation for insulin resistance.
methodsBlood sampling was conducted in male dogs to determine 24 h profiles of NEFA at baseline and during high-fat feeding with and without acute nocturnal NEFA suppression using a partial A1 adenosine receptor agonist.
resultsHigh-fat feeding increased nocturnal NEFA and reduced insulin sensitivity, effects countered by an increase in acute insulin response to glucose (AIR(g)). Pharmacological NEFA inhibition after 8 weeks of high-fat feeding lowered NEFA to baseline levels and reduced AIR(g) with no effect on insulin sensitivity. A significant relationship emerged between nocturnal NEFA levels and AIR(g). This relationship indicates that the hyperinsulinaemic compensation induced in response to high-fat feeding was prevented when the nocturnal NEFA pattern was returned to baseline. CONCLUSIONS/
interpretationElevated nocturnal NEFA are an important signal for hyperinsulinaemic compensation during diet-induced insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.