Evidence map›Paper›PMID 26254445›Full record

Trial reportBMJ (Clinical research ed.)2015

Comparison of hospital variation in acute myocardial infarction care and outcome between Sweden and United Kingdom: population based cohort study using nationwide clinical registries.

Sheng-Chia Chung, Johan Sundström, Chris P Gale, Stefan James, John Deanfield, Lars Wallentin, Adam Timmis, Tomas Jernberg, Harry Hemingway, Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies/Register of Information and Knowledge about Swedish Heart Intensive care Admissions and 2 more

Registry-linked trialAbstract readClinical TrialComparative StudyMulticenter Study
In one paragraph

Trial report in BMJ (Clinical research ed.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01359033 (Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01359033 completednot on this map

Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden

TypeobservationalSponsorUniversity College, LondonRan2011 to 2014Enrolled510,863ConditionsAcute Myocardial Infarction
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study.European heart journal. Quality of care & clinical outcomes · 2024
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  15. Expansion of off-site percutaneous coronary intervention centres significantly reduces ambulance driving time to primary PCI in the Netherlands.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sheng-Chia ChungFarr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London NW1 2DA, UK s.chung@ucl.ac.uk.
Johan SundströmDepartment of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden Uppsala Clinical Research Center, Uppsala, Sweden.
Chris P GaleCardiovascular Health Sciences, University of Leeds, Leeds, UK.
Stefan JamesDepartment of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden Uppsala Clinical Research Center, Uppsala, Sweden.
John DeanfieldNational Centre for Cardiovascular Prevention and Outcomes, London, UK.
Lars WallentinDepartment of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden Uppsala Clinical Research Center, Uppsala, Sweden.
Adam TimmisNational Institute for Health Research, Cardiovascular Biomedical Research Unit, Bart's Health London, London, UK.
Tomas JernbergDepartment of Medicine, Huddinge, Section of Cardiology, Karolinska Institute, Stockholm, Sweden.
Harry HemingwayFarr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London NW1 2DA, UK.
Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies/Register of Information and Knowledge about Swedish Heart Intensive care Admissions
National Institute for Cardiovascular Outcomes Research/Myocardial Ischaemia National Audit Project
CAardiovascular Disease Research Using Linked Bespoke Studies and Electronic Health Records

Funding

British Heart FoundationCancer Research UKChief Scientist OfficeDepartment of Health RP-PG-0407-10314Medical Research Council G0902393/99558Medical Research Council MR/K006584/1Medical Research Council MR/L01629X/1Medical Research Council MR/M015084/1Wellcome Trust 086091/Z/08/Z
6 · The paper itself

Abstract

objectiveTo assess the between hospital variation in use of guideline recommended treatments and clinical outcomes for acute myocardial infarction in Sweden and the United Kingdom.

designPopulation based longitudinal cohort study using nationwide clinical registries. SETTING AND

participantsNationwide registry data comprising all hospitals providing acute myocardial infarction care in Sweden (SWEDEHEART/RIKS-HIA, n=87; 119,786 patients) and the UK (NICOR/MINAP, n=242; 391,077 patients), 2004-10.

main outcome measuresBetween hospital variation in 30 day mortality of patients admitted with acute myocardial infarction.

resultsCase mix standardised 30 day mortality from acute myocardial infarction was lower in Swedish hospitals (8.4%) than in UK hospitals (9.7%), with less variation between hospitals (interquartile range 2.6% v 3.5%). In both countries, hospital level variation and 30 day mortality were inversely associated with provision of guideline recommended care. Compared with the highest quarter, hospitals in the lowest quarter for use of primary percutaneous coronary intervention had higher volume weighted 30 day mortality for ST elevation myocardial infarction (10.7% v 6.6% in Sweden; 12.7% v 5.8% in the UK). The adjusted odds ratio comparing the highest with the lowest quarters for hospitals' use of primary percutaneous coronary intervention was 0.70 (95% confidence interval 0.62 to 0.79) in Sweden and 0.68 (0.60 to 0.76) in the UK. Differences in risk between hospital quarters of treatment for non-ST elevation myocardial infarction and secondary prevention drugs for all discharged acute myocardial infarction patients were smaller than for reperfusion treatment in both countries.

conclusionBetween hospital variation in 30 day mortality for acute myocardial infarction was greater in the UK than in Sweden. This was associated with, and may be partly accounted for by, the higher practice variation in acute myocardial infarction guideline recommended treatment in the UK hospitals. High quality healthcare across all hospitals, especially in the UK, with better use of guideline recommended treatment, may not only reduce unacceptable practice variation but also deliver improved clinical outcomes for patients with acute myocardial infarction. Clinical trials registration Clinical trials NCT01359033.

Indexed as

AdultAgedCardiotonic AgentsCohort StudiesDiagnosis-Related GroupsFemaleGuideline AdherenceHospitalizationHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPractice Guidelines as TopicProfessional PracticeCardiotonic Agents

Identifiers

PMID26254445
PMCPMC4528190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.