ReviewCold Spring Harbor perspectives in biology2015
Intracellular Scaling Mechanisms.
Review in Cold Spring Harbor perspectives in biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation.bioRxiv : the preprint server for biology · 2025Article
- Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells.Current biology : CB · 2025Article
- Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells.bioRxiv : the preprint server for biology · 2025Article
- Catalytic growth in a shared enzyme pool ensures robust control of centrosome size.bioRxiv : the preprint server for biology · 2024Article
- Length control emerges from cytoskeletal network geometry.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes.Nature genetics · 2024Article
- Length control emerges from cytoskeletal network geometry.bioRxiv : the preprint server for biology · 2023Article
- The large cytoplasmic volume of oocyte.The Journal of reproduction and development · 2023Review
- Centriole growth is limited by the Cdk/Cyclin-dependent phosphorylation of Ana2/STIL.The Journal of cell biology · 2022Article
- How Metabolic Rate Relates to Cell Size.Biology · 2022Review
- Evolutionary divergence of anaphase spindle mechanics in nematode embryos constrained by antagonistic pulling and viscous forces.Molecular biology of the cell · 2022Article
- How to assemble a scale-invariant gradient.eLife · 2022Article
- Whole and Purified Aqueous Extracts ofCells · 2022Article
- A feedback control principle common to several biological and engineered systems.Journal of the Royal Society, Interface · 2022Review
- Volumetric morphometry reveals spindle width as the best predictor of mammalian spindle scaling.The Journal of cell biology · 2022Article
- Characterization and differentiation potential of mesenchymal stem cells isolated from multiple canine adipose tissue sources.BMC veterinary research · 2021Article
- A quantitative analysis of cerebellar anatomy in birds.Brain structure & function · 2021Article
- The cerebellar anatomy of red junglefowl and white leghorn chickens: insights into the effects of domestication on the cerebellum.Royal Society open science · 2021Article
- Article
- Activity-dependent compensation of cell size is vulnerable to targeted deletion of ion channels.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Organelle function is often directly related to organelle size. However, it is not necessarily absolute size but the organelle-to-cell-size ratio that is critical. Larger cells generally have increased metabolic demands, must segregate DNA over larger distances, and require larger cytokinetic rings to divide. Thus, organelles often must scale to the size of the cell. The need for scaling is particularly acute during early development during which cell size can change rapidly. Here, we highlight scaling mechanisms for cellular structures as diverse as centrosomes, nuclei, and the mitotic spindle, and distinguish them from more general mechanisms of size control. In some cases, scaling is a consequence of the underlying mechanism of organelle size control. In others, size-control mechanisms are not obviously related to cell size, implying that scaling results indirectly from cell-size-dependent regulation of size-control mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.