ReviewJournal of immunology (Baltimore, Md. : 1950)2015
T Cell Adolescence: Maturation Events Beyond Positive Selection.
Review in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- PD-1 regulates latent effector differentiation of thymic cytotoxic CD8Nature communications · 2026Article
- UBL3 Participates in the Early Stages of CD83-Dependent CD4European journal of immunology · 2026Article
- Single-cell transcriptome delineating asymmetric dynamics of CD4Frontiers in immunology · 2026Article
- Dynamic Synthesis of Multi-Modal Representations for CITE-seq Data Integration and Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo.The Journal of experimental medicine · 2025Article
- Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development.The Journal of experimental medicine · 2024Review
- Leveraging genetics to investigate causal effects of immune cell phenotypes in periodontitis: a mendelian randomization study.Frontiers in genetics · 2024Article
- Coronin 1-dependent cell density sensing and regulation of the peripheral T cell population size.Oxford open immunology · 2024Review
- Ikaros is a principal regulator of AireScience immunology · 2023Article
- Single-cell multiomic analysis of thymocyte development reveals drivers of CD4Nature immunology · 2023Article
- Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4ImmunoHorizons · 2022Article
- ICAP-1 loss impairs CD8European journal of immunology · 2022Article
- Protein ubiquitination in T cell development.Frontiers in immunology · 2022Review
- Tetraploid Ancestry Provided Atlantic Salmon With Two Paralogue Functional T Cell Receptor Beta Regions Whereof One Is Completely Novel.Frontiers in immunology · 2022Article
- SRSF1 Deficiency Impairs the Late Thymocyte Maturation and the CD8 Single-Positive Lineage Fate Decision.Frontiers in immunology · 2022Article
- Generation of highly proliferative, rejuvenated cytotoxic T cell clones through pluripotency reprogramming for adoptive immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- Article
- Thymus Extracellular Matrix-Derived Scaffolds Support Graft-Resident Thymopoiesis and Long-Term In Vitro Culture of Adult Thymic Epithelial Cells.Advanced functional materials · 2021Article
- SRSF1 serves as a critical posttranscriptional regulator at the late stage of thymocyte development.Science advances · 2021Article
- SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development.Frontiers in immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Single-positive thymocytes that successfully complete positive and negative selection must still undergo one final step, generally termed T cell maturation, before they gain functional competency and enter the long-lived T cell pool. Maturation initiates after positive selection in single-positive thymocytes and continues in the periphery in recent thymic emigrants, before these newly produced T cells gain functional competency and are ready to participate in the immune response as peripheral naive T cells. Recent work using genetically altered mice demonstrates that T cell maturation is not a single process, but a series of steps that occur independently and sequentially after positive selection. This review focuses on the changes that occur during T cell maturation, as well as the molecules and pathways that are critical at each step.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.