ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2015
Seasonal acclimatization of the cardiac potassium currents (IK1 and IKr) in an arctic marine teleost, the navaga cod (Eleginus navaga).
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 38 citations in OpenAlex.
- Subchronic PAH Exposure Impacts Cardiac Electrophysiology of the Polar Fish, Navaga Cod (Toxics · 2026Article
- The Dependence of the Electrophysiological Effects of Class III Antiarrhythmic Drug Refralon on the Frequency of Myocardium Activation.Bulletin of experimental biology and medicine · 2023Article
- Seasonal changes of electrophysiological heterogeneities in the rainbow trout ventricular myocardium.Current research in physiology · 2022Article
- Effect of atrial artificial electrical stimulation on depolarization and repolarization and hemodynamics of the heart ventricle in rainbow trout Oncorhynchus mykiss.Fish physiology and biochemistry · 2021Article
- Phenanthrene alters the electrical activity of atrial and ventricular myocytes of a polar fish, the Navaga cod.Aquatic toxicology (Amsterdam, Netherlands) · 2021Article
- Ionic basis of atrioventricular conduction: ion channel expression and sarcolemmal ion currents of the atrioventricular canal of the rainbow trout (Oncorhynchus mykiss) heart.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Cardiophysiological responses of the air-breathing Alaska blackfish to cold acclimation and chronic hypoxic submergence at 5°C.The Journal of experimental biology · 2020Article
- A characterization of the electrophysiological properties of the cardiomyocytes from ventricle, atrium and sinus venosus of the snake heart.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Transcript expression of inward rectifier potassium channels of Kir2 subfamily in Arctic marine and freshwater fish species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Contractile performance of the Alaska blackfish (Dallia pectoralis) ventricle: Assessment of the effects of temperature, pacing frequency, the role of the sarcoplasmic reticulum in contraction and adrenergic stimulation.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2019Article
- Electrophysiological differences in cholinergic signaling between the hearts of summer and winter frogs (Rana temporaria).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Seasonal changes of cholinergic response in the atrium of Arctic navaga cod (Eleginus navaga).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Several freshwater fishes of north-temperate latitudes exhibit marked seasonal changes in cardiac action potential (AP) waveform as an outcome of temperature-dependent changes in the density of delayed rectifiers (IKr, IKs) and inward rectifier (IK1) potassium currents. Thus far, ionic mechanisms of cardiac excitability in arctic marine fishes have not been examined. To this end we examined ventricular AP and the role of two major potassium currents (IK1, IKr) in repolarization of cardiac AP in winter-acclimatized (WA, caught in March) and summer-acclimatized (SA, caught in September) navaga cod (Eleginus navaga) of the White Sea. The duration of ventricular AP of WA navaga at 3 °C (APD50 = 659.5 ± 32.8 ms) was similar to the AP duration of SA navaga at 12 °C (APD50 = 543.9 ± 14.6 ms) (p > 0.05) indicating complete thermal compensation of AP duration. This acclimation effect was associated with strong up-regulation of the cardiac potassium currents in winter. Densities of ventricular IK1 (at -120 mV) and IKr (at +50 mV) of the WA navaga at 3 °C were 2.9 times and 2.8 times, respectively, higher than those of the SA navaga at 12 °C, thus indicating marked thermal overcompensation. Qualitatively similar results were obtained from atrial myocytes. Seasonal changes in IK1 and IKr are more than sufficient to explain the complete thermal compensation of ventricular AP duration. The excellent acclimation capacity of cardiac excitability of the navaga cod is probably needed to maintain high cardiac performance at subzero temperatures in winter and to increase thermal resilience of cardiac function under seasonally variable arctic temperature conditions.
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