ArticleFertility and sterility2015
Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality.
Article in Fertility and sterility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The banned sunscreen ingredients and their impact on human health: a systematic review.International journal of dermatology · 2020Pooled it
- Review
- Negative Paper Spray Ionization Mass Spectrometry for the Determination of Endocrine-Disrupting Chemicals with Application to Paraben Analysis in Cosmetics.Molecules (Basel, Switzerland) · 2025Article
- Endocrine and Reproductive Health Considerations of Sunscreen UV Filters: Insights from a Comprehensive Review 2014-2024.Current environmental health reports · 2025Review
- Ultraviolet Filters: Dissecting Current Facts and Myths.Journal of clinical medicine · 2024Review
- A review of sources, pathways, and toxic effects of human exposure to benzophenone ultraviolet light filters.Eco-Environment & Health · 2024Review
- Review on photoprotection: a clinician's guide to the ingredients, characteristics, adverse effects, and disease-specific benefits of chemical and physical sunscreen compounds.Archives of dermatological research · 2023Review
- Towards a paradigm shift in environmental health decision-making: a case study of oxybenzone.Environmental health : a global access science source · 2022Review
- Urinary benzophenones and synthetic progestin in Chinese adults and children: concentration, source and exposure.Environmental science and pollution research international · 2021Article
- UV filters in matched seminal fluid-, urine-, and serum samples from young men.Journal of exposure science & environmental epidemiology · 2021Article
- Environmental Distribution of Personal Care Products and Their Effects on Human Health.Iranian journal of pharmaceutical research : IJPR · 2021Review
- Cutaneous Photoprotection: A Review of the Current Status and Evolving Strategies.The Yale journal of biology and medicine · 2020Review
- Benzophenone-2 Concentration and Its Effect on Oxidative Stress and Apoptosis Markers in Rat Brain.Neurotoxicity research · 2019Article
- Exposome-wide association study of semen quality: Systematic discovery of endocrine disrupting chemical biomarkers in fertility require large sample sizes.Environment international · 2019Article
- Time-to-Pregnancy Associated With Couples' Use of Tobacco Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Observational
- Couples' urinary concentrations of benzophenone-type ultraviolet filters and the secondary sex ratio.The Science of the total environment · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo assess benzophenone-type ultraviolet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints.
designCohort.
settingNot applicable. PATIENT(S): A total of 413 men provided semen and urine samples, 2005-2009. Five UV filters were quantified (ng/mL) in urine using liquid chromatography-triple quadrupole mass spectrometry: BP-1 (2,4-dihydroxybenzophenone), BP-2 (2,2',4,4'-tetrahydroxybenzophenone), BP-3 (2-hydroxy-4-methoxybenzophenone), BP-8 (2,2'-dihydroxy-4-methoxybenzophenone), and 4-OH-BP (4-hydroxybenzophenone). Using linear regression, β-coefficients (β) and 95% confidence intervals (CIs) for each chemical dichotomized at the 75th percentile and Box-Cox transformed semen endpoint were estimated, after adjusting for age, body mass index, cotinine, season, and site. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Thirty-five semen endpoints. RESULT(S): BP-2 was associated with diminished sperm concentration (β = -0.74; 95% CI -1.41, -0.08), straight (β = -4.57; 95% CI -8.95, -0.18) and linear movement (β = -3.15; 95% CI -6.01, -0.30), more immature sperm (β = 0.38; 95% CI 0.15, 0.62), and a decreased percentage of other tail abnormalities (β = -0.16; 95% CI -0.31, -0.01). BP-8 was associated with decreased hypo-osmotic swelling (β = -2.57; 95% CI -4.86, -0.29) and higher acrosome area (β = 1.14; 95% CI 0.01, 2.26). No associations were observed for BP-1, BP-3, or 4OH-BP. CONCLUSION(S): The findings suggest that specific UV filters may be associated with some aspects of semen endpoints, but await future corroboration.
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