ArticleNeuroradiology2015
Disease-specific structural changes in thalamus and dentatorubrothalamic tract in progressive supranuclear palsy.
Article in Neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Dynamic [Molecular neurodegeneration · 2026Article
- Subregional thalamic atrophy in Progressive Supranuclear Palsy: A machine learning study.NeuroImage. Clinical · 2026Article
- Brainstem and cerebellar radiological findings in progressive supranuclear palsy.Brain communications · 2025Review
- Assisted Parkinsonism Diagnosis Using Multimodal MRI-The Role of Clinical Insights.Brain and behavior · 2025Article
- Acoustic Analysis and Neuroimaging Correlates of Diadochokinetic Rates in Mild-Moderate Primary Progressive Apraxia of Speech.Brain and language · 2023Article
- Sensitivity of Diffusion MRI to White Matter Pathology: Influence of Diffusion Protocol, Magnetic Field Strength, and Processing Pipeline in Systemic Lupus Erythematosus.Frontiers in neurology · 2022Article
- Investigating the Anatomy and Microstructure of the Dentato-rubro-thalamic and Subthalamo-ponto-cerebellar Tracts in Parkinson's Disease.Frontiers in neurology · 2022Article
- Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies.Nature reviews. Neurology · 2021Review
- Diffusion tensor imaging analysis in three progressive supranuclear palsy variants.Journal of neurology · 2021Article
- Dentatorubrothalamic tract reduction using fixel-based analysis in corticobasal syndrome.Neuroradiology · 2021Article
- The Role of Magnetic Resonance Imaging for the Diagnosis of Atypical Parkinsonism.Frontiers in neurology · 2020Review
- Evidence for Reciprocal Structural Network Interactions Between Bilateral Crus Lobes and Broca's Complex.Frontiers in neuroanatomy · 2020Article
- Modern Brainstem MRI Techniques for the Diagnosis of Parkinson's Disease and Parkinsonisms.Frontiers in neurology · 2020Review
- Diffusion Tensor MRI to Distinguish Progressive Supranuclear Palsy from α-Synucleinopathies.Radiology · 2019Article
- Differentiation of multiple system atrophy from Parkinson's disease by structural connectivity derived from probabilistic tractography.Scientific reports · 2019Article
- Mapping of apparent susceptibility yields promising diagnostic separation of progressive supranuclear palsy from other causes of parkinsonism.Scientific reports · 2019Article
- Track density imaging in progressive supranuclear palsy: A pilot study.Human brain mapping · 2019Article
- Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy.NeuroImage. Clinical · 2019Article
- Improved Neuroimaging Atlas of the Dentate Nucleus.Cerebellum (London, England) · 2017Article
- Magnetic resonance imaging for the diagnosis of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study is to identify disease-specific changes of the thalamus, basal ganglia, pons, and midbrain in patients with progressive supranuclear palsy (PSP), Parkinson's disease (PD), and multiple system atrophy with predominant parkinsonism (MSA-P) using diffusion tensor imaging and volumetric analysis.
methodsMRI diffusion and volumetric data were acquired in a derivation of 30 controls and 8 patients with PSP and a validation cohort comprised of controls (n = 21) and patients with PSP (n = 27), PD (n = 10), and MSA-P (n = 11). Analysis was performed using regions of interest (ROI), tract-based spatial statistic (TBSS), and tractography and results compared between diagnostic groups.
resultsIn the derivation cohort, we observed increased mean diffusivity (MD) in the thalamus, superior cerebellar peduncle, and the midbrain in PSP compared to controls. Furthermore, volumetric analysis showed reduced thalamic volumes in PSP. In the validation cohort, the observations of increased MD were replicated by ROI-based analysis and in the thalamus by TBSS-based analysis. Such differences were not found for patients with PD in any of the cohorts. Tractography of the dentatorubrothalamic tract (DRTT) showed increased MD in PSP patients from both cohorts compared to controls and in the validation cohort in PSP compared to PD and MSA patients. Increased MD in the thalamus and along the DRTT correlated with disease stage and motor function in PSP.
conclusionPatients with PSP, but not PD or MSA-P, exhibit signs of structural abnormalities in the thalamus and in the DRTT. These changes are associated with disease stage and impaired motor function.
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