Evidence map›Paper›PMID 26253765›Full record

ArticleDiabetologia2015

Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes.

Anita Kondrashova, Noora Nurminen, Maarit Patrikainen, Heini Huhtala, Jussi Lehtonen, Jorma Toppari, Jorma Ilonen, Olli G Simell, Riitta Veijola, Mikael Knip and 1 more

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Article in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Antibody Cross-Reactivity in Auto-Immune Diseases.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Review
  6. Childhood Vaccinations and Type 1 Diabetes.Frontiers in immunology · 2021
    Review
  7. Type 1 diabetes-early life origins and changing epidemiology.The lancet. Diabetes & endocrinology · 2020
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Anita KondrashovaSchool of Medicine, University of Tampere, Biokatu 10, FIN-33520, Tampere, Finland.
Noora NurminenSchool of Medicine, University of Tampere, Biokatu 10, FIN-33520, Tampere, Finland.
Maarit PatrikainenSchool of Medicine, University of Tampere, Biokatu 10, FIN-33520, Tampere, Finland.
Heini HuhtalaSchool of Health Sciences, University of Tampere, Tampere, Finland.
Jussi LehtonenSchool of Medicine, University of Tampere, Biokatu 10, FIN-33520, Tampere, Finland.
Jorma ToppariDepartment of Physiology, University of Turku, Turku, Finland.
Jorma IlonenDepartment of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland.
Olli G SimellDepartment of Pediatrics, Turku University Hospital, Turku, Finland.
Riitta VeijolaDepartment of Pediatrics, University of Oulu, Oulu, Finland.
Mikael KnipChildren's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Heikki HyötySchool of Medicine, University of Tampere, Biokatu 10, FIN-33520, Tampere, Finland. Heikki.Hyoty@uta.fi.
Tampere University · FITampere University · FIUniversity of Turku · FITurku University Hospital · FIUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisViral infections have long been considered potential triggers of beta cell autoimmunity and type 1 diabetes. Recent studies have suggested that influenza A virus might increase the risk of type 1 diabetes. The present study evaluates this risk association in prospectively observed children at the time when islet autoimmunity starts and autoantibodies are first detected.

methodsIgG class antibodies to influenza A virus were analysed in 95 case children whose antibody screening test turned permanently positive for two or more islet autoantibodies and from 186 autoantibody-negative and non-diabetic control children who were matched for time of birth, sex, date of sampling and HLA-conferred risk of diabetes in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study. Virus antibodies were measured from the first autoantibody-positive sample using an enzyme immunoassay. None of the children had been vaccinated against influenza A.

resultsThe prevalence of influenza A virus antibodies did not differ between the case and control children (42% vs 38%; p = 0.392) and the median antibody levels were also comparable in the two groups (3.0 vs 3.8 enzyme immunoassay units). A similar result was obtained when case and control children were compared separately in subgroups according to different sex, age and HLA-DQ genotype. However, girls had higher antibody levels than boys among both case and control children (median antibody levels 9.0 vs 2.3 enzyme immunoassay units; p = 0.01). CONCLUSIONS/

interpretationOur results suggest that influenza A infections are not associated with the development of islet autoimmunity in young children with increased genetic susceptibility to type 1 diabetes.

Indexed as

Genetic Predisposition to DiseaseAdolescentAntibodies, ViralAutoantibodiesAutoimmunityChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGenotypeHumansInfantInfluenza A virusIslets of LangerhansMaleAntibodies, ViralAutoantibodiesInfluenza A virusType 1 diabetesVirus antibodies

Identifiers

PMID26253765
OpenAlexW1857489441

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.