ArticleJournal of biomechanics2015
Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development.
Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Biomechanical strain patterns in Meckel's cartilage underlie mandibular variation in FGFR2 mouse models.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Beyond mammals: the evolution of chewing and other forms of oropharyngeal food processing in vertebrates.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Nkx2.7 is a conserved regulator of craniofacial development.Nature communications · 2025Article
- Compressive stress gradients direct mechanoregulation of anisotropic growth in the zebrafish jaw joint.PLoS computational biology · 2024Article
- Two zebrafish cacna1s loss-of-function variants provide models of mild and severe CACNA1S-related myopathy.Human molecular genetics · 2024Article
- A Zebrafish Mutant in the Extracellular Matrix Protein GeneAnimals : an open access journal from MDPI · 2023Article
- Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Biophysical models of early mammalian embryogenesis.Stem cell reports · 2023Review
- Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish.Journal of anatomy · 2022Article
- Extracellular Matrix in Human Craniofacial Development.Journal of dental research · 2022Review
- FACEts of mechanical regulation in the morphogenesis of craniofacial structures.International journal of oral science · 2021Review
- Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity.Nature communications · 2020Article
- Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.Journal of the Royal Society, Interface · 2019Article
- Interactions among ryanodine receptor isotypes contribute to muscle fiber type development and function.Disease models & mechanisms · 2019Article
- Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Muscle-induced loading as an important source of variation in craniofacial skeletal shape.Genesis (New York, N.Y. : 2000) · 2019Article
- The mechanical impact ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- A quantitative analysis of 3D-cell distribution in regenerating muscle-skeletal system with synchrotron X-ray computed microtomography.Scientific reports · 2018Article
- Stresses and strains on the human fetal skeleton during development.Journal of the Royal Society, Interface · 2018Article
- Mechanical regulation of musculoskeletal system development.Development (Cambridge, England) · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Abnormal joint morphogenesis is linked to clinical conditions such as Developmental Dysplasia of the Hip (DDH) and to osteoarthritis (OA). Muscle activity is known to be important during the developmental process of joint morphogenesis. However, less is known about how this mechanical stimulus affects the behaviour of joint cells to generate altered morphology. Using zebrafish, in which we can image all joint musculoskeletal tissues at high resolution, we show that removal of muscle activity through anaesthetisation or genetic manipulation causes a change to the shape of the joint between the Meckel's cartilage and Palatoquadrate (the jaw joint), such that the joint develops asymmetrically leading to an overlap of the cartilage elements on the medial side which inhibits normal joint function. We identify the time during which muscle activity is critical to produce a normal joint. Using Finite Element Analysis (FEA), to model the strains exerted by muscle on the skeletal elements, we identify that minimum principal strains are located at the medial region of the joint and interzone during mouth opening. Then, by studying the cells immediately proximal to the joint, we demonstrate that biomechanical strain regulates cell orientation within the developing joint, such that when muscle-induced strain is removed, cells on the medial side of the joint notably change their orientation. Together, these data show that biomechanical forces are required to establish symmetry in the joint during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.