ArticleApplied and environmental microbiology2015
Circulation of Coxiella burnetii in a Naturally Infected Flock of Dairy Sheep: Shedding Dynamics, Environmental Contamination, and Genotype Diversity.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Human Q fever outbreak investigation and management in six European countries: a One Health compendium of practices and recommendations.CMI communications · 2026Review
- Molecular detection ofVeterinary and animal science · 2026Article
- Prevalence and risk factors of neglected zoonoses in Ethiopian small ruminants: a focus on Q fever, brucellosis, chlamydiosis, and toxoplasmosis.One health outlook · 2026Article
- Molecular detection of Coxiella burnetii in vaginal and rectal swab samples of small ruminants from Kermanshah Province, western Iran.BMC veterinary research · 2026Article
- Impact of whole-herd vaccination on a caprine coxiellosis outbreak: a longitudinal study ofFrontiers in microbiology · 2026Article
- Molecular characterization ofFrontiers in veterinary science · 2026Article
- Review
- Combination of serology and PCR analysis of environmental samples to assessApplied and environmental microbiology · 2025Article
- Metabarcoding analysis of the microbiota in flocks naturally infected byOne health (Amsterdam, Netherlands) · 2025Article
- Pre-purchase screening forFrontiers in veterinary science · 2025Article
- Characterising Eastern Grey Kangaroos (Microorganisms · 2024Article
- Two Years afterAnimals : an open access journal from MDPI · 2023Article
- Tracking the Source of Human Q Fever from a Southern French Village: Sentinel Animals and Environmental Reservoir.Microorganisms · 2023Article
- Performance Evaluation and Validation of Air Samplers To Detect Aerosolized Coxiella burnetii.Microbiology spectrum · 2022Article
- Surveillance ofVeterinary sciences · 2022Article
- Impact ofFrontiers in veterinary science · 2022Article
- Comparison ofPathogens (Basel, Switzerland) · 2020Article
- MonitoringFrontiers in veterinary science · 2020Article
- Review
- Genotyping of Coxiella burnetii in sheep and goat abortion samples.BMC microbiology · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Q fever is a worldwide zoonosis caused by Coxiella burnetii. Domestic ruminants are considered to be the main reservoir. Sheep, in particular, may frequently cause outbreaks in humans. Because within-flock circulation data are essential to implementing optimal management strategies, we performed a follow-up study of a naturally infected flock of dairy sheep. We aimed to (i) describe C. burnetii shedding dynamics by sampling vaginal mucus, feces, and milk, (ii) assess circulating strain diversity, and (iii) quantify barn environmental contamination. For 8 months, we sampled vaginal mucus and feces every 3 weeks from aborting and nonaborting ewes (n=11 and n=26, respectively); for lactating females, milk was obtained as well. We also sampled vaginal mucus from nine ewe lambs. Dust and air samples were collected every 3 and 6 weeks, respectively. All samples were screened using real-time PCR, and strongly positive samples were further analyzed using quantitative PCR. Vaginal and fecal samples with sufficient bacterial burdens were then genotyped by multiple-locus variable-number tandem-repeat analysis (MLVA) using 17 markers. C. burnetii burdens were higher in vaginal mucus and feces than in milk, and they peaked in the first 3 weeks postabortion or postpartum. Primiparous females and aborting females tended to shed C. burnetii longer and have higher bacterial burdens than nonaborting and multiparous females. Six genotype clusters were identified; they were independent of abortion status, and within-individual genotype diversity was observed. C. burnetii was also detected in air and dust samples. Further studies should determine whether the within-flock circulation dynamics observed here are generalizable.
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