ArticleMolecular systems biology2015
Extensive allele-specific translational regulation in hybrid mice.
Article in Molecular systems biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents.Cell proliferation · 2026Article
- Translatomics to explore dynamic differences in immunocytes in the tumor microenvironment.Molecular therapy. Nucleic acids · 2023Review
- Normal Alpha-1-Antitrypsin Variants Display in Serum Allele-Specific Protein Levels.Journal of proteome research · 2023Article
- Ribosome profiling reveals the translational landscape and allele-specific translational efficiency in rice.Plant communications · 2023Article
- DeeReCT-APA: Prediction of Alternative Polyadenylation Site Usage Through Deep Learning.Genomics, proteomics & bioinformatics · 2022Article
- Translational control by DHX36 binding to 5'UTR G-quadruplex is essential for muscle stem-cell regenerative functions.Nature communications · 2021Article
- Predicting mean ribosome load for 5'UTR of any length using deep learning.PLoS computational biology · 2021Article
- Systematic Analysis of Monoallelic Gene Expression and Chromatin Accessibility Across Multiple Tissues in Hybrid Mice.Frontiers in cell and developmental biology · 2021Article
- Selection of Cashmere Fineness Functional Genes by Translatomics.Frontiers in genetics · 2021Article
- Article
- CRISPR-assisted detection of RNA-protein interactions in living cells.Nature methods · 2020Article
- Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus.Nature communications · 2019Article
- Selective translational usage of TSS and core promoters revealed by translatome sequencing.BMC genomics · 2019Article
- Pervasive allele-specific regulation on RNA decay in hybrid mice.Life science alliance · 2018Article
- Increased proteomic complexity inScience advances · 2018Article
- RNA Regulations and Functions Decoded by Transcriptome-wide RNA Structure Probing.Genomics, proteomics & bioinformatics · 2017Review
- Gene Regulation and Speciation.Trends in genetics : TIG · 2017Review
- Global analysis of regulatory divergence in the evolution of mouse alternative polyadenylation.Molecular systems biology · 2016Article
- Control of Gene Expression by RNA Binding Protein Action on Alternative Translation Initiation Sites.PLoS computational biology · 2016Article
- Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.Nature communications · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translational regulation is mediated through the interaction between diffusible trans-factors and cis-elements residing within mRNA transcripts. In contrast to extensively studied transcriptional regulation, cis-regulation on translation remains underexplored. Using deep sequencing-based transcriptome and polysome profiling, we globally profiled allele-specific translational efficiency for the first time in an F1 hybrid mouse. Out of 7,156 genes with reliable quantification of both alleles, we found 1,008 (14.1%) exhibiting significant allelic divergence in translational efficiency. Systematic analysis of sequence features of the genes with biased allelic translation revealed that local RNA secondary structure surrounding the start codon and proximal out-of-frame upstream AUGs could affect translational efficiency. Finally, we observed that the cis-effect was quantitatively comparable between transcriptional and translational regulation. Such effects in the two regulatory processes were more frequently compensatory, suggesting that the regulation at the two levels could be coordinated in maintaining robustness of protein expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.