Evidence map›Paper›PMID 26253327›Full record

ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016

Outcomes after inappropriate nuclear myocardial perfusion imaging: A meta-analysis.

Islam Y Elgendy, Ahmed Mahmoud, Jonathan J Shuster, Rami Doukky, David E Winchester

Abstract readMulticenter StudyReview
In one paragraph

Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. ASNC SPECT-MPI quality metrics: a race to the top.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  4. Quality metrics for single-photon emission computed tomography myocardial perfusion imaging: an ASNC information statement.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  5. The prognostic and diagnostic implications of surveillance serial myocardial perfusion imaging in asymptomatic renal transplant candidates.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  6. Evaluation of the impact of laboratory accreditation on downstream outcomes.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  7. The prognostic value of regadenoson SPECT myocardial perfusion imaging: The largest cohort to date.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  8. Using a sledgehammer to crack a nut: The burdensome appropriate use criteria program.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  9. Article
  10. Article
  11. More or less appropriate: The new rule of law for cardiac imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  12. Article
  13. Article
  14. What's accepted is not always appropriate!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  15. ASNC imaging guidelines for nuclear cardiology procedures : Standardized reporting of nuclear cardiology procedures.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
  16. Review of cardiovascular imaging in the journal of nuclear cardiology in 2016: Part 2 of 2-myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Review
  17. Article
  18. An application of meta-analysis based on DerSimonian and Laird method.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Article
  19. Review of Cardiovascular Imaging in the Journal of Nuclear Cardiology in 2015-Part 2 of 2: Myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Islam Y ElgendyDivision of Cardiovascular Medicine, University of Florida College of Medicine, 1600 SW Archer Rd, PO Box 100277, Gainesville, FL, 32610, USA.
Ahmed MahmoudDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Jonathan J ShusterDepartment of Health Outcomes and Policy, University of Florida, Gainesville, FL, USA.
Rami DoukkyDivision of Cardiology, Rush University Medical Center, Chicago, IL, USA.
David E WinchesterDivision of Cardiovascular Medicine, University of Florida College of Medicine, 1600 SW Archer Rd, PO Box 100277, Gainesville, FL, 32610, USA. david.winchester@medicine.ufl.edu.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427
6 · The paper itself

Abstract

backgroundThe relationship between inappropriate MPI and cardiovascular outcomes is poorly understood. We sought to systematically review the literature on appropriate use criteria (AUC) for MPI, including temporal trend of inappropriate testing and resulting cardiovascular outcomes.

methodsWe searched the MEDLINE database for studies related to AUC and MPI. The co-primary outcomes were abnormal test results and the presence of cardiac ischemia. Random effects odds ratios (OR) were constructed using DerSimonian-Laird method.

resultsA total of 22 studies with 23,443 patients were included. The prevalence of inappropriate testing was 14.8% [95% confidence interval (CI) 11.6%-18.7%]. Inappropriate MPI studies were less likely to be abnormal (OR 0.41 95% CI 0.35-0.49, P < .0001) and to demonstrate ischemia (OR 0.40, 95% CI 0.24-0.67, P < .0001) compared to appropriate testing. No difference in the rate of inappropriate tests was detected based on the midpoint of the enrollment year (P = .54). The pattern of ordering inappropriate studies was not different between cardiology and non-cardiology providers (OR 0.74, 95% CI 0.51-1.06, P = .10).

conclusionInappropriate MPI studies are less likely to yield abnormal results or demonstrate myocardial ischemia. The rate of inappropriate MPI has not decreased over time.

Indexed as

AgedDiagnostic ErrorsFemaleHumansMaleMEDLINEMiddle AgedMyocardial IschemiaMyocardial Perfusion ImagingPrevalenceReproducibility of ResultsRisk FactorsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonUnnecessary ProceduresUtilization ReviewischemiamyocardialMyocardial perfusion imagingPETSPECT

Identifiers

PMID26253327
PMCPMC5442883

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.