Evidence map›Paper›PMID 26253296›Full record

ArticleInflammation2016

Citrate Attenuates Adenine-Induced Chronic Renal Failure in Rats by Modulating the Th17/Treg Cell Balance.

Yan Ou, Shuiqin Li, Xiaojing Zhu, Baosong Gui, Ganglian Yao, Liqun Ma, Dan Zhu, Rongguo Fu, Heng Ge, Li Wang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yan OuDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China. yanousx@163.com.
Shuiqin LiDepartment of Rehabilitation Medicine, Yan'an University Affiliated Hospital, Yan'an, 716000, Shaanxi, China.
Xiaojing ZhuDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Baosong GuiDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Ganglian YaoDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Liqun MaDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Dan ZhuDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Rongguo FuDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Heng GeDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Li WangDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Lining JiaDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Lifang TianDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Zhaoyang DuanDepartment of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 the Fifth Western Street, Xi'an, 710004, Shaanxi, China.
Second Affiliated Hospital of Xi'an Jiaotong University · CNYanan University Affiliated Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Citrate is commonly used as an anticoagulant in hemodialysis for chronic renal failure (CRF) and for the regulation of the immune dysfunction in CRF patients. The objective of this study was to investigate the effect of citrate on the balance of T helper 17 (Th17) and regulatory T (Treg) cells in CRF. The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were significantly increased in the CRF model group compared to the control group, and were decreased in the citrate-treated groups. Citrate treatment inhibited the viability of Th17 cells while elevating the viability of Treg cells in CRF rats. Moreover, Th17-related cytokines significantly decreased while the Treg-related cytokines significantly increased with citrate treatment. Moreover, citrate had a negative influence on the deviation of Th17/Treg cells in CRF rats. Therefore, our study suggests that citrate had an anti-inflammatory effect on CRF through the modulation of the Th17/Treg balance.

Indexed as

AdenineAnimalsAnti-Inflammatory AgentsBlood Urea NitrogenCell SurvivalCitric AcidCreatinineCytokinesDisease Models, AnimalForkhead Transcription FactorsInflammationKidney Failure, ChronicNuclear Receptor Subfamily 1, Group F, Member 3RatsRats, Sprague-DawleyTh17 CellsAdenineAnti-Inflammatory AgentsCitric AcidCreatinineCytokinesForkhead Transcription FactorsFoxp3 protein, ratNuclear Receptor Subfamily 1, Group F, Member 3chronic renal failurecitrateregulatory T cellsTh17 cells

Identifiers

PMID26253296
OpenAlexW2269479867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.