Evidence map›Paper›PMID 26253196›Full record

ArticleCell stem cell2015

Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs.

Kyoko Ito, Keisuke Ito

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kyoko ItoRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Keisuke ItoRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Albert Einstein Cancer Center and Einstein Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: keisuke.ito@einstein.yu.edu.
Albert Einstein College of Medicine · US

Funding

The Roles of Lipid Metabolism in the Maintenance of Hematopoietic Stem CellsR01DK098263 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Keisuke Ito · 2013 to 2026
$5.2M
Epigenetic regulation by microRNA of MDS pathogenesisR01DK100689 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ITO, KEISUKE · 2014 to 2017
$1.0M
NIDDK NIH HHS R01 DK098263NIDDK NIH HHS R01 DK100689
6 · The paper itself

Abstract

Therapeutic targeting of pre-leukemic stem cells (pre-LSCs) may be a viable strategy to eradicate residual disease and prevent leukemia relapse. Now in Cell Stem Cell, Cai et al. (2015) show that loss-of-function mutations in RUNX1 reduce ribosome biogenesis and provide pre-LSCs a selective advantage over normal hematopoietic cells through increased stress resistance.

Indexed as

Organelle BiogenesisAnimalsCore Binding Factor Alpha 2 SubunitHematopoietic Stem CellsHumansRibosomesCore Binding Factor Alpha 2 Subunit

Identifiers

PMID26253196
PMCPMC4541802
OpenAlexW1848132744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.