Evidence map›Paper›PMID 26252915›Full record

ArticleJournal of pediatric gastroenterology and nutrition2016

Prevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children.

Arik Alper, Steven Hardee, Danilo Rojas-Velasquez, Sandra Escalera, Raffaella A Morotti, Dinesh S Pashankar

Abstract read
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Cellular and molecular basis of proximal small intestine disorders.Nature reviews. Gastroenterology & hepatology · 2024
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arik Alper*Department of Pediatrics, Division of Pediatric Gastroenterology †Department of Pathology, Yale University School of Medicine, New Haven, CT.
Steven Hardee
Danilo Rojas-Velasquez
Sandra Escalera
Raffaella A Morotti
Dinesh S Pashankar
Yale University · US

Funding

TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · NIDDK · YALE UNIVERSITY · PI Fred Sanford Gorelick, Liza Konnikova · 1986 to 2026
$7.1M
NIDDK NIH HHS T32 DK 007017NIDDK NIH HHS T32 DK007017
6 · The paper itself

Abstract

objectivesAlthough gastritis and esophagitis are well studied in children, there is very limited literature on duodenitis in children. We aimed to assess the prevalence, etiology, clinical, endoscopic, and pathological features in a large cohort of unselected children with duodenitis.

methodsWe reviewed the pathology reports of all the upper endoscopies performed at our institution during 5 years to identify children with duodenitis. Biopsy sections were reviewed to confirm the diagnosis of duodenitis. Demographic, clinical, endoscopic data, and the presence of associated gastritis and esophagitis were noted in all of the children with duodenitis. The etiology of duodenitis was correlated with the patients' clinical diagnosis.

resultsOut of 2772 children who had endoscopy, 352 had duodenitis with the prevalence rate of 12.7%. Gastritis was seen in 64% of children with duodenitis compared with 46% of children without duodenitis (P < 0.001). Common indications for endoscopy in children with duodenitis were abdominal pain, positive celiac serology, and diarrhea. The most common etiology was celiac disease (32%), followed by Crohn disease (13%), ulcerative colitis (3%), and Helicobacter pylori infection (6%). In 63% of cases, the endoscopic appearance of duodenum was normal. Cryptitis, villous changes, and cellular infiltration were noted on histology.

conclusionsPrevalence of duodenitis is 12.7% in children undergoing endoscopy. Celiac disease and inflammatory bowel disease are common causes of duodenitis. Associated gastritis is common in children with duodenitis, and the correlation of endoscopic appearance with histology is poor.

Indexed as

DuodenitisEndoscopyAbdominal PainAdolescentCeliac DiseaseChildChild, PreschoolColitis, UlcerativeCrohn DiseaseDiarrheaDuodenumFemaleGastritisHelicobacter InfectionsHumansInfant

Identifiers

PMID26252915
PMCPMC4724230
OpenAlexW1122574352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.