SynthesisPloS one2015
Comparison of Porcine Small Intestinal Submucosa versus Polypropylene in Open Inguinal Hernia Repair: A Systematic Review and Meta-Analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- A multicenter randomized controlled trial comparing short- and medium-term outcomes of novel biologics and lightweight synthetic mesh for laparoscopic inguinal hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2024Trial
- Outcomes of porcine small intestinal submucosa mesh compared to polypropylene mesh in laparoscopic transabdominal preperitoneal inguinal hernia repair: a retrospective cohort study.Surgical endoscopy · 2025Article
- Porcine small intestine graft for reconstruction of oral defects.Laryngoscope investigative otolaryngology · 2021Article
- Decellularization and In Vivo Recellularization of Abdominal Porcine Fascial Tissue.Tissue engineering and regenerative medicine · 2021Article
- Regulatory science for hernia mesh: Current status and future perspectives.Bioactive materials · 2021Review
- Lichtenstein inguinal hernia repairs with porcine small intestine submucosa: a 5- year follow-up. a prospective randomized controlled study.Regenerative biomaterials · 2021Article
- Creation of Tissue-Engineered Urethras for Large Urethral Defect Repair in a Rabbit Experimental Model.Frontiers in pediatrics · 2021Article
- Evaluation of decellularization protocols for production of porcine small intestine submucosa for use in abdominal wall reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- What is the evidence for the use of biologic or biosynthetic meshes in abdominal wall reconstruction?Hernia : the journal of hernias and abdominal wall surgery · 2018Review
- Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair.Advanced drug delivery reviews · 2018Review
- Extracellular matrix-based biomaterial scaffolds and the host response.Biomaterials · 2016Review
- Biological Meshes for Inguinal Hernia Repair - Review of the Literature.Frontiers in surgery · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA systematic review and meta-analysis was performed in randomized controlled trials (RCTs) to compare porcine small intestinal submucosa (SIS) with polypropylene in open inguinal hernia repair.
methodElectronic databases MEDLINE, Embase, and the Cochrane Library were used to compare patient outcomes for the two groups via meta-analysis.
resultA total of 3 randomized controlled trials encompassing 200 patients were included in the meta-analysis. There was no significant difference in recurrence (P = 0.16), hematomas (P = 0.06), postoperative pain within 30 days (P = 0.45), or postoperative pain after 1 year (P = 0.12) between the 2 groups. The incidence of discomfort was significantly lower (P = 0.0006) in the SIS group. However, the SIS group experienced a significantly higher incidence of seroma (P = 0.03).
conclusionsCompared to polypropylene, using SIS in open inguinal hernia repair is associated with a lower incidence of discomfort and a higher incidence of seroma. However, well-designed larger RCT studies with a longer follow-up period are needed to confirm these findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.