ArticlePLoS neglected tropical diseases2015
Taenia solium: Development of an Experimental Model of Porcine Neurocysticercosis.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Experimental animal models and their use in understanding cysticercosis: A systematic review.PloS one · 2022Pooled it
- Neuroimaging Features of an Experimental Model of Extraparenchymal Neurocysticercosis.Acta parasitologica · 2026Article
- Histopathological, immunohistochemical, and molecular characterization of Coenurus cerebralis infection in sheep with evaluation of cerebrospinal cytokine responses.Parasitology research · 2026Article
- Neurocysticercosis by Taenia sp. in a female alpaca (Vicugna pacos) from Germany.BMC veterinary research · 2026Article
- Taenia solium neurocysticercosis: Its current epidemiological, diagnostic, therapeutic, and control landscapes.PLoS neglected tropical diseases · 2026Review
- Long-Term Neuroimaging Findings in a Murine Model of Human Extraparenchymal Neurocysticercosis.ACS infectious diseases · 2025Article
- Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction.Frontiers in immunology · 2025Article
- Murine Extraparenchymal Neurocysticercosis: Appropriate Model for Evaluating Anthelminthic and Anti-Inflammatory Treatment Schedules.Tropical medicine and infectious disease · 2024Article
- Oxidative Stress in the Murine Model of Extraparenchymal Neurocysticercosis.Microorganisms · 2024Article
- Standardizing an Experimental Murine Model of Extraparenchymal Neurocysticercosis That Immunologically Resembles Human Infection.Brain sciences · 2023Article
- Porcine model of neurocysticercosis by intracarotid injection of Taenia solium oncospheres: Dose assessment, infection outcomes and serological responses.PLoS neglected tropical diseases · 2022Article
- New animal models of neurocysticercosis can help understand epileptogenesis in neuroinfection.Frontiers in molecular neuroscience · 2022Article
- Taenia solium Cysticercosis and Its Impact in Neurological Disease.Clinical microbiology reviews · 2020Review
- Host immune responses during Taenia solium Neurocysticercosis infection and treatment.PLoS neglected tropical diseases · 2020Review
- Association between helminth infections and diabetes mellitus in adults from the Lao People's Democratic Republic: a cross-sectional study.Infectious diseases of poverty · 2018Article
- CarotidThe American journal of tropical medicine and hygiene · 2018Article
- TNF-α blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis.PLoS neglected tropical diseases · 2017Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human neurocysticercosis (NC) is caused by the establishment of Taenia solium larvae in the central nervous system. NC is a severe disease still affecting the population in developing countries of Latin America, Asia, and Africa. While great improvements have been made on NC diagnosis, treatment, and prevention, the management of patients affected by extraparenchymal parasites remains a challenge. The development of a T. solium NC experimental model in pigs that will allow the evaluation of new therapeutic alternatives is herein presented. Activated oncospheres (either 500 or 1000) were surgically implanted in the cerebral subarachnoid space of piglets. The clinical status and the level of serum antibodies in the animals were evaluated for a 4-month period after implantation. The animals were sacrificed, cysticerci were counted during necropsy, and both the macroscopic and microscopic characteristics of cysts were described. Based on the number of established cysticerci, infection efficiency ranged from 3.6% (1000 oncospheres) to 5.4% (500 oncospheres). Most parasites were caseous or calcified (38/63, 60.3%) and were surrounded by an exacerbated inflammatory response with lymphocyte infiltration and increased inflammatory markers. The infection elicited specific antibodies but no neurological signs. This novel experimental model of NC provides a useful tool to evaluate new cysticidal and anti-inflammatory approaches and it should improve the management of severe NC patients, refractory to the current treatments.
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