Evidence map›Paper›PMID 26252718›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2015

Association of Serum Uric Acid Level With Blood Pressure Variability in Newly Diagnosed Essential Hypertension.

Kumral Çağlı, Osman Turak, Uğur Canpolat, Fırat Özcan, Derya Tok, Mehmet Ali Mendi, Fatih Öksüz, Dimitrie Siriopol, Gabriel Veisa, Adrian Covic and 1 more

Abstract read
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
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  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Effect of Social, regional, and education status and season on blood pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2019
    Article
  12. Hyperuricemia and Hypertension: Links and Risks.Integrated blood pressure control · 2019
    Review
  13. Article
  14. Article
  15. Article
  16. Could Uric Acid Be Considered a Cardiovascular Risk Factor?Journal of clinical hypertension (Greenwich, Conn.) · 2015
    Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kumral ÇağlıCardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Osman TurakCardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Uğur CanpolatCardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Fırat ÖzcanCardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Derya TokCardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Mehmet Ali MendiCardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Fatih ÖksüzCardiology Clinic, Türkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Dimitrie SiriopolNephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
Gabriel VeisaNephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
Adrian CovicNephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
Mehmet KanbayDivision of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum uric acid (UA) is independently associated with hypertension and blood pressure (BP) variability (BPV) is associated with cardiovascular events and mortality in hypertensive patients. The aim of the present study was to assess the association of serum UA with BPV in 300 untreated essential hypertension patients (mean age 57.3±13.6 years). BPV was quantified as the standard deviation (SD) of the 24-hour, daytime, and nighttime mean values obtained by using ambulatory BP monitoring. In correlation analysis, log UA values were found to be positively correlated with 24-hour systolic BPV and nighttime systolic and diastolic BPV (Pearson coefficients of 0.246, 0.280, and 0.353, respectively; P<.001 for all). In multivariate analysis, log UA had an independent association with 24-hour systolic BPV and nighttime systolic and diastolic BPV. This study show for the first time that increased serum UA is independently associated with BPV in untreated essential hypertension patients.

Indexed as

AgedBlood PressureBlood Pressure DeterminationBlood Pressure Monitoring, AmbulatoryCircadian RhythmCross-Sectional StudiesEssential HypertensionFemaleHumansHypertensionMaleMiddle AgedUric AcidUric Acid

Identifiers

PMID26252718
PMCPMC8031696

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.