ArticleHuman brain mapping2015
The primary somatosensory cortex and the insula contribute differently to the processing of transient and sustained nociceptive and non-nociceptive somatosensory inputs.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Somatosensory Deficits After Stroke: Insights From MRI Studies.Frontiers in neurology · 2022Pooled it
- Efficacy and Mechanisms of Combined Central-Peripheral Magnetic Stimulation on Prefrontal-Sensorimotor Cortex Connectivity in Post-Stroke Dysphagia after Supratentorial Stroke: A Randomized, Single-Blind, Parallel-Controlled Trial.Translational stroke research · 2026Trial
- Sensory Afferent Neural Circuits Mediate Electroacupuncture to Improve Swallowing Function in a Post-Stroke Dysphagia Mouse Model.CNS neuroscience & therapeutics · 2025Article
- Short-latency afferent inhibition is reduced with cold-water immersion of a limb and remains reduced after removal from the cold stimulus.Experimental physiology · 2024Article
- Pain and Reorganization after Amputation: Is Interoceptive Prediction a Key?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Article
- Cognitive and affective interaction with somatosensory afference in acupuncture-a specific brain response to compound stimulus.Frontiers in human neuroscience · 2023Article
- Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia.Human brain mapping · 2022Article
- Intensity-dependent modulation of cortical somatosensory processing during external, low-frequency peripheral nerve stimulation in humans.Journal of neurophysiology · 2022Article
- Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice.The Journal of experimental medicine · 2022Article
- Altered structural covariance and functional connectivity of the insula in patients with Crohn's disease.Quantitative imaging in medicine and surgery · 2022Article
- Cerebral structural alterations in the patients undergoing postherpetic neuralgia: A VBM-MRI study.Ibrain · 2022Article
- Informing the study of suicidal thoughts and behaviors in distressed young adults: The use of a machine learning approach to identify neuroimaging, psychiatric, behavioral, and demographic correlates.Psychiatry research. Neuroimaging · 2021Article
- Test-retest reliability of laser evoked pain perception and fMRI BOLD responses.Scientific reports · 2021Article
- Similarities and Differences Between Vestibular and Cochlear Systems - A Review of Clinical and Physiological Evidence.Frontiers in neuroscience · 2021Review
- Painful Seizures: a Review of Epileptic Ictal Pain.Current pain and headache reports · 2019Review
- Brain regions preferentially responding to transient and iso-intense painful or tactile stimuli.NeuroImage · 2019Article
- Differential Effects of Sustained Manual Pressure Stimulation According to Site of Action.Frontiers in neuroscience · 2019Article
- Decomposing Gratitude: Representation and Integration of Cognitive Antecedents of Gratitude in the Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects.Pain research & management · 2018Article
- A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity.Nature neuroscience · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Transient nociceptive stimuli elicit consistent brain responses in the primary and secondary somatosensory cortices (S1, S2), the insula and the anterior and mid-cingulate cortex (ACC/MCC). However, the functional significance of these responses, especially their relationship with sustained pain perception, remains largely unknown. Here, using functional magnetic resonance imaging, we characterize the differential involvement of these brain regions in the processing of sustained nociceptive and non-nociceptive somatosensory input. By comparing the spatial patterns of activity elicited by transient (0.5 ms) and long-lasting (15 and 30 s) stimuli selectively activating nociceptive or non-nociceptive afferents, we found that the contralateral S1 responded more strongly to the onset of non-nociceptive stimulation as compared to the onset of nociceptive stimulation and the sustained phases of nociceptive and non-nociceptive stimulation. Similarly, the anterior insula responded more strongly to the onset of nociceptive stimulation as compared to the onset of non-nociceptive stimulation and the sustained phases of nociceptive and non-nociceptive stimulation. This suggests that S1 is specifically sensitive to changes in incoming non-nociceptive input, whereas the anterior insula is specifically sensitive to changes in incoming nociceptive input. Second, we found that the MCC responded more strongly to the onsets as compared to the sustained phases of both nociceptive and non-nociceptive stimulation, suggesting that it could be involved in the detection of change regardless of sensory modality. Finally, the posterior insula and S2 responded maximally during the sustained phase of non-nociceptive stimulation but not nociceptive stimulation, suggesting that these regions are preferentially involved in processing non-nociceptive somatosensory input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.