ArticlePloS one2015
Determination of Parameters for the Supercritical Extraction of Antioxidant Compounds from Green Propolis Using Carbon Dioxide and Ethanol as Co-Solvent.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
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- In-Depth Phytochemical Profile by LC-MS/MS, Mineral Content by ICP-MS, and In-Vitro Antioxidant, Antidiabetic, Antiepilepsy, Anticholinergic, and Antiglaucoma Properties of Bitlis Propolis.Life (Basel, Switzerland) · 2024Article
- Optimization of Antifungal Properties of Hop Cone Carbon Dioxide Extracts Based on Response Surface Methodology.Molecules (Basel, Switzerland) · 2024Article
- Integrated HS-GC-IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of different citrus peels.Current research in food science · 2024Article
- Characterization and stability evaluation of Egyptian propolis extract nano-capsules and their application.Scientific reports · 2023Article
- Extraction of Antioxidant Compounds from Brazilian Green Propolis Using Ultrasound-Assisted Associated with Low- and High-Pressure Extraction Methods.Molecules (Basel, Switzerland) · 2023Article
- Phenolic Constituents, Antioxidant and Antimicrobial Activity and Clustering Analysis of Propolis Samples Based on PCA from Different Regions of Anatolia.Molecules (Basel, Switzerland) · 2023Article
- Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment.Pharmaceutics · 2022Article
- Edible oils as a co-extractant for the supercritical carbon dioxide extraction of flavonoids from propolis.PloS one · 2022Article
- Evaluation of the Skin-Sensitizing Potential of Brazilian Green Propolis.International journal of molecular sciences · 2021Article
- Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp.BMC complementary medicine and therapies · 2021Article
- Activity of Ethanolic and Supercritical Propolis Extracts inFrontiers in veterinary science · 2021Article
- Supercritical Extraction of Red Propolis: Operational Conditions and Chemical Characterization.Molecules (Basel, Switzerland) · 2020Article
- Extraction, Antioxidant Capacity, 5-Lipoxygenase Inhibition, and Phytochemical Composition of Propolis from Eastern Canada.Molecules (Basel, Switzerland) · 2020Article
- Effect of Experimental Parameters on the Extraction of Grape Seed Oil Obtained by Low Pressure and Supercritical Fluid Extraction.Molecules (Basel, Switzerland) · 2020Article
- Metal Content of Nutritional and Toxic Value in Different Types of Brazilian Propolis.TheScientificWorldJournal · 2020Article
- Susceptibility ofFrontiers in veterinary science · 2019Article
- The Application of Supercritical Fluid Extraction in Phenolic Compounds Isolation from Natural Plant Materials.Molecules (Basel, Switzerland) · 2018Review
- Article
- Chitosan-propolis nanoparticle formulation demonstrates anti-bacterial activity against Enterococcus faecalis biofilms.PloS one · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine the best processing conditions to extract Brazilian green propolis using a supercritical extraction technology. For this purpose, the influence of different parameters was evaluated such as S/F (solvent mass in relation to solute mass), percentage of co-solvent (1 and 2% ethanol), temperature (40 and 50°C) and pressure (250, 350 and 400 bar) using supercritical carbon dioxide. The Global Yield Isotherms (GYIs) were obtained through the evaluation of the yield, and the chemical composition of the extracts was also obtained in relation to the total phenolic compounds, flavonoids, antioxidant activity and 3,5-diprenyl-4-hydroxicinnamic acid (Artepillin C) and acid 4-hydroxycinnamic (p-coumaric acid). The best results were identified at 50°C, 350 bar, 1% ethanol (co-solvent) and S/F of 110. These conditions, a content of 8.93±0.01 and 0.40±0.05 g/100 g of Artepillin C and p-coumaric acid, respectively, were identified indicating the efficiency of the extraction process. Despite of low yield of the process, the extracts obtained had high contents of relevant compounds, proving the viability of the process to obtain green propolis extracts with important biological applications due to the extracts composition.
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