ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2015
Disappearing liver metastases from colorectal cancer: impact of modern imaging modalities.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Missing colorectal liver metastases: the surgical challenge.Langenbeck's archives of surgery · 2021Pooled it
- Imaging in disappearing colorectal liver metastases and their accuracy: a systematic review.World journal of surgical oncology · 2020Pooled it
- Management Strategies for Disappearing Colorectal Liver Metastases After Systemic Chemotherapy: Long-Term Outcomes and Preoperative Prediction of 'True Complete Response'.Annals of gastroenterological surgery · 2026Article
- Diagnostic Accuracy of Imaging in Assessing Nonviability of Disappearing Colorectal Liver Metastasis.JAMA surgery · 2025Article
- Gadoxetic acid-enhanced magnetic resonance imaging to predict pathologic complete response of colorectal liver metastases in preoperative chemotherapy.Scientific reports · 2025Article
- New trends in surgery for colorectal liver metastasis.Annals of gastroenterological surgery · 2024Review
- Review
- Multisocietal European consensus on the terminology, diagnosis, and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE.The British journal of surgery · 2023Article
- Disappearing Colorectal Liver Metastases: Do We Really Need a Ghostbuster?Healthcare (Basel, Switzerland) · 2022Review
- The Influence of Radiological "Disappearing Lesions" on the Efficacy and Prognosis of Patients with Colorectal Liver Metastases Undergoing Conversion Therapy.Gastroenterology research and practice · 2022Article
- Current role of intraoperative ultrasonography in hepatectomy.Surgery today · 2021Review
- Utility of Image Guidance in the Localization of Disappearing Colorectal Liver Metastases.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
- Eradication of Missing Liver Metastases After Fiducial Placement.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChemotherapy is often used before a resection for colorectal liver metastases. After chemotherapy, metastases may disappear on cross-sectional imaging but residual metastatic disease may still exist. The aim of this retrospective study was to investigate the impact of new advancements in imaging technology such as magnetic resonance imaging (MRI) with liver-specific contrast (Gd-EOB-DTPA) and contrast-enhanced intra-operative ultrasound (CE-IOUS) on disappearing liver metastases (DLM).
methodsTwenty-nine patients with one or more DLM undergoing surgical exploration were included. Pre-operative imaging consisted of contrast-enhanced multi-detector computed tomography (MDCT) and/or MRI with liver-specific contrast. At surgery, CE-IOUS was used when tumours known from pre-chemotherapy imaging were not found by inspection or intra-operative ultrasound.
resultsPatients presented 66 DLM. At surgical exploration, 42 DLM were identified and treated (64%). CE-IOUS detected one additional DLM not found by intra-operative ultrasound. For metastases ≤10 mm on histological analysis, imaging sensitivities for MRI and MDCT before surgery but after chemotherapy were 26/49 (53%) and 24/66 (36%), respectively.
conclusionA majority of DLM are identified during surgery using intra-operative ultrasound, with only little additional value of CE-IOUS. The sensitivities of post-chemotherapy imaging modalities for small metastases are low in the setting of DLM. For surgical planning, an optimized pre-chemotherapy imaging is essential.
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