Evidence map›Paper›PMID 26252399›Full record

ReviewPeriodontology 20002015

Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis.

Frank A Roberts, Richard P Darveau

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Periodontology 2000, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05666622 (Can Delta Neutrophil Index Values Predict the Success of Periodontal Treatment in Patients With Periodontitis?), which is not on this map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05666622 nacompletednot on this mapstarted 2020, after this paper: background citation

Can Delta Neutrophil Index Values Predict the Success of Periodontal Treatment in Patients With Periodontitis?

TypeinterventionalSponsorKahramanmaras Sutcu Imam UniversityRan2020 to 2022Enrolled70ConditionsPeriodontitis, Periodontal Inflammation, Inflammatory ResponseArmsOnly routine non-surgical periodontal treatment was applied to the patients.
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
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  8. Journal of bacteriology · 2026
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  14. Advances in Fecal Microbiota Transplantation for Gut Dysbiosis-Related Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Frank A Roberts
Richard P Darveau
University of Washington · US

Funding

P. GINGIVALIS LPS-MODULATION OF INNATE HOST DEFENSER01DE012768 · NIDCR · UNIVERSITY OF WASHINGTON · PI DARVEAU, RICHARD PETERS · 1999 to 2014
$5.0M
Oral Commensal Bacterial Modulation of the Periodontal Innate Host ResponseR01DE018274 · NIDCR · UNIVERSITY OF WASHINGTON · PI DARVEAU, RICHARD PETERS · 2007 to 2010
$1.2M
NIDCR NIH HHS R01 DE012768NIDCR NIH HHS R01 DE018274
6 · The paper itself

Abstract

This review discusses polymicrobial interactions with the host in both health and disease. As our ability to identify specific bacterial clonal types, with respect to their abundance and location in the oral biofilm, improves, we will learn more concerning their contribution to both oral health and disease. Recent studies examining host- bacteria interactions have revealed that commensal bacteria not only protect the host simply by niche occupation, but that bacterial interactions with host tissue can promote the development of proper tissue structure and function. These data indicate that our host-associated polymicrobial communities, such as those found in the oral cavity, co-evolved with us and have become an integral part of who we are. Understanding the microbial community factors that underpin the associations with host tissue that contribute to periodontal health may also reveal how dysbiotic periodontopathic oral communities disrupt normal periodontal tissue functions in disease. A disruption of the oral microbial community creates dysbiosis, either by overgrowth of specific or nonspecific microorganisms or by changes in the local host response where the community can now support a disease state. Dysbiosis provides the link between systemic changes (e.g. diabetes) and exogenous risk factors (e.g. smoking), and the dysbiotic community, and can drive the destruction of periodontal tissue. Many other risk factors associated with periodontal disease, such as stress, aging and genetics, are also likely to affect the microbial community, and more research is needed, utilizing sophisticated bacterial taxonomic techniques, to elucidate these effects on the microbiome and to develop strategies to target the dysbiotic mechanisms and improve periodontal health.

Indexed as

Bacterial Physiological PhenomenaDysbiosisSymbiosisAnimalsBiofilmsHost-Pathogen InteractionsHumansMicrobiotaMouthPeriodontitisPeriodontiumVirulence

Identifiers

PMID26252399
PMCPMC4530467
OpenAlexW2102915615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.