ArticlePloS one2015
The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Transcriptome Analysis Identifies the Crosstalk between Dendritic and Natural Killer Cells in Human Cutaneous Leishmaniasis.Microorganisms · 2023Article
- Novel research synergized by Chinese medicine pattern classification in rheumatoid arthritis.Clinical rheumatology · 2022Article
- Identification of Hub Genes in Type 2 Diabetes Mellitus Using Bioinformatics Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Identification of Shared Molecular Signatures Indicate the Susceptibility of Endometriosis to Multiple Sclerosis.Frontiers in genetics · 2018Article
- Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis.Journal of immunology research · 2018Article
- Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study.Scientific reports · 2017Article
- 3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation.Scientific reports · 2017Article
- Article
- Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis.Mediators of inflammation · 2017Article
- Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology andFrontiers in pharmacology · 2017Article
- Integration of Chinese medicine with Western medicine could lead to future medicine: molecular module medicine.Chinese journal of integrative medicine · 2016Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) and Type 2 diabetes (T2D) are both systemic diseases linked with altered immune response, moderate mortality when present together. The treatment for both RA and T2D are not satisfied, partly because of the linkage between them has not yet been appreciated. A comprehensive study for the potential associations between the two disorders is needed. In this study, we used RNA sequencing to explore the differently expressed genes (DEGs) in peripheral blood mononuclear cells (PBMC) of 10 RA and 10 T2D patients comparing with 10 healthy volunteers (control). We used bioinformatics analysis and the Ingenuity Pathways Analysis (IPA) to predict the commonalities on signaling pathways and molecular networks between those two diseases. 212 DEGs in RA and 114 DEGs in T2D patients were identified compared with healthy controls, respectively. 32 DEGs were shared between the two comparisons. The top 10 shared pathways interacted in cross-talking networks, regulated by 5 shared predicted upstream regulators, leading to the activated immune response were explored, which was considered as partly of the association mechanism of this two disorders. These discoveries would be considered as new understanding on the associations between RA and T2D, and provide novel treatment or prevention strategy.
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