Evidence map›Paper›PMID 26252205›Full record

ArticlePloS one2015

Plasma Concentrations of Hepcidin in Anemic Zimbabwean Infants.

Tatenda G Mupfudze, Rebecca J Stoltzfus, Sandra Rukobo, Lawrence H Moulton, Jean H Humphrey, Andrew J Prendergast, SHINE Trial Team, Andrew D Jones, Amee Manges, Goldberg Mangwadu and 4 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00198718 phase2completednot on this map

Vitamin A Supplementation of Breast Feeding Mothers and Their Neonates at Delivery: Impact on Mother to Child Transmission of HIV During Lactation, HIV Infection Among Women During the Postpartum Year, and Infant Mortality.

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan1997 to 2020Enrolled28,220ConditionsVitamin A Deficiency, HIVArmsVitamin A (retinyl palmitate)
NCT01824940 nacompletednot on this map

Sanitation, Hygiene, Infant Nutrition Efficacy Project

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2012 to 2017Enrolled5,280ConditionsGrowth, Stunting, Nutritional, AnemiaArmsStandard care, WASH, Infant and young child feeding, WASH and Nutrition
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Tatenda G MupfudzeDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Rebecca J StoltzfusDivision of Nutritional Sciences, Cornell University, Ithaca, NY, United States of America.
Sandra RukoboZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Lawrence H MoultonDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
Jean H HumphreyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Andrew J PrendergastDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Blizard Institute, Queen Mary University of London, London, United Kingdom.
SHINE Trial Team
Andrew D Jones
Amee Manges
Goldberg Mangwadu
John A Maluccio
Mduduzi N N Mbuya
Robert Ntozini
James M Tielsch
Johns Hopkins University · USZvitambo Institute for Maternal and Child Health Research · ZWCornell University · USQueen Mary University of London · GB

Funding

Effect of a sanitation & nutrition intervention on HIV-exposed infant healthR01HD060338 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HUMPHREY, JEAN HAWES · 2008 to 2012
$2.0M
NICHD NIH HHS R01 HD060338NICHD NIH HHS R01HD060338-01Wellcome Trust 093768/Z/10/ZWellcome Trust 100714
6 · The paper itself

Abstract

objectiveAnemia in infancy is a global public health problem. We evaluated the relative contributions of iron deficiency and inflammation to infant anemia.

methodsWe measured plasma hepcidin, ferritin, soluble transferrin receptor (sTfR), alpha-1-acid glycoprotein and C-reactive protein (CRP) by ELISA on archived plasma from 289 HIV-unexposed anemic or non-anemic Zimbabwean infants at ages 3 mo, 6 mo and 12 mo. Among anemic infants, we determined the proportion with iron-deficiency anemia (IDA) and anemia of inflammation (AI). We undertook regression analyses of plasma hepcidin and anemia status, adjusting for sex, age and birthweight.

resultsAnemic infants at 3 mo were more stunted and had higher CRP (median 0.45 vs 0.21 mg/L; P = 0.037) and hepcidin (median 14.7 vs 9.7 ng/mL; P = 0.022) than non-anemic infants, but similar levels of ferritin and sTfR; 11% infants had IDA and 15% had AI. Anemic infants at 6 mo had higher hepcidin (median 7.9 vs 4.5 ng/mL; P = 0.016) and CRP (median 2.33 vs 0.32 mg/L; P<0.001), but lower ferritin (median 13.2 vs 25.1 μg/L; P<0.001) than non-anemic infants; 56% infants had IDA and 12% had AI. Anemic infants at 12 mo had lower ferritin (median 3.2 vs 22.2 μg/L; P<0.001) and hepcidin (median 0.9 vs 1.9 ng/mL; P = 0.019), but similar CRP levels; 48% infants had IDA and 8% had AI. Comparing anemic with non-anemic infants, plasma hepcidin was 568% higher, 405% higher and 64% lower at 3 mo, 6 mo and 12 mo, respectively, after adjusting for sex and birthweight (all p<0.01). Plasma hepcidin declined significantly with age among anemic but not non-anemic infants. Girls had 61% higher hepcidin than boys, after adjusting for age, anemia and birthweight (p<0.001).

conclusionAnemia is driven partly by inflammation early in infancy, and by iron deficiency later in infancy, with plasma hepcidin concentrations reflecting the relative contribution of each. However, there is need to better characterize the drivers of hepcidin during infancy in developing countries.

Indexed as

AnemiaAnemia, Iron-DeficiencyBiomarkersBirth WeightC-Reactive ProteinCross-Sectional StudiesDietary SupplementsEnzyme-Linked Immunosorbent AssayFemaleFerritinsHepcidinsHIV InfectionsHumansInfantInflammationIronBiomarkersC-Reactive ProteinFerritinsHepcidinsIronOrosomucoidReceptors, TransferrinVitamin A

Identifiers

PMID26252205
PMCPMC4529326
OpenAlexW1102922142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.