ArticleEndocrinology2015
The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats.
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation.Reviews in endocrine & metabolic disorders · 2026Review
- Unveiling the gut: microbiota and derived metabolites' role in the rising tide of precocious puberty.Frontiers in microbiology · 2026Review
- The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin.The Journal of clinical endocrinology and metabolism · 2025Review
- Neuronal network dynamics in the posterodorsal amygdala: shaping reproductive hormone pulsatility.Journal of the Royal Society, Interface · 2024Article
- NK3R signalling in the posterodorsal medial amygdala is involved in stress-induced suppression of pulsatile LH secretion in female mice.Journal of neuroendocrinology · 2024Article
- Postweaning Social Isolation Alters Puberty Onset by Suppressing Electrical Activity of Arcuate Kisspeptin Neurons.Neuroendocrinology · 2024Article
- Introduction: What Are Dendritic Spines?Advances in neurobiology · 2023Article
- Posterodorsal Medial Amygdala Urocortin-3, GABA, and Glutamate Mediate Suppression of LH Pulsatility in Female Mice.Endocrinology · 2022Article
- GABA Signaling in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice.Endocrinology · 2022Article
- GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice.Journal of neuroendocrinology · 2022Article
- Role of Posterodorsal Medial Amygdala Urocortin-3 in Pubertal Timing in Female Mice.Frontiers in endocrinology · 2022Article
- Current Perspectives on Kisspeptins Role in Behaviour.Frontiers in endocrinology · 2022Review
- Sex differences in the coexpression of prokineticin receptor 2 and gonadal steroids receptors in mice.Frontiers in neuroanatomy · 2022Article
- Urocortin3 in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice.Endocrinology · 2021Article
- Kisspeptin modulates gamma-aminobutyric acid levels in the human brain.Psychoneuroendocrinology · 2021Article
- Puberty, A Sensitive Window of Hypothalamic Development and Plasticity.Endocrinology · 2021Review
- Pubertal development mediates the association between family environment and brain structure and function in childhood.Development and psychopathology · 2020Article
- Role of the posterodorsal medial amygdala in predator odour stress-induced puberty delay in female rats.Journal of neuroendocrinology · 2019Article
- Medial Amygdala Kiss1 Neurons Mediate Female Pheromone Stimulation of Luteinizing Hormone in Male Mice.Neuroendocrinology · 2019Article
- Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice.Journal of neuroendocrinology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Obesity is the major risk factor for early puberty, but emerging evidence indicates other factors including psychosocial stress. One key brain region notable for its role in controlling calorie intake, stress, and behavior is the amygdala. Early studies involving amygdala lesions that included the medial nucleus advanced puberty in rats. More recently it was shown that a critical site for lesion-induced hyperphagia and obesity is the posterodorsal subnucleus of the medial amygdala (MePD), which may explain the advancement of puberty. Glutamatergic activity also increases in the MePD during puberty without a corresponding γ-aminobutyric acid (GABA)ergic change, suggesting an overall activation of this brain region. In the present study, we report that neurotoxic lesioning of the MePD advances puberty and increases weight gain in female rats fed a normal diet. However, MePD lesioned rats fed a 25% nonnutritive bulk diet also showed the dramatic advancement of puberty but without the increase in body weight. In both dietary groups, MePD lesions resulted in an increase in socialization and a decrease in play fighting behavior. Chronic GABAA receptor antagonism in the MePD from postnatal day 21 for 14 days also advanced puberty, increased socialization, and decreased play fighting without altering body weight, whereas glutamate receptor antagonism delayed puberty and decreased socialization without affecting play fighting. In conclusion, our results suggest the MePD regulates the timing of puberty via a novel mechanism independent of change in body weight and caloric intake. MePD glutamatergic systems advance the timing of puberty whereas local GABAergic activation results in a delay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.