Evidence map›Paper›PMID 26251892›Full record

ArticleMolecules (Basel, Switzerland)2015

The Stability, Sustained Release and Cellular Antioxidant Activity of Curcumin Nanoliposomes.

Xing Chen, Li-Qiang Zou, Jing Niu, Wei Liu, Sheng-Feng Peng, Cheng-Mei Liu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 400 citations in OpenAlex.

  1. Trial
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  11. Review
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  13. Curcumin in Fibrosis Treatment: A Review.Drug design, development and therapy · 2026
    Review
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  15. Review
  16. Advanced Oral Delivery Systems for Nutraceuticals.Advanced healthcare materials · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. NanoencapsulatedMolecules (Basel, Switzerland) · 2025
    Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xing ChenState Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China. ncuskchenxing@163.com.
Li-Qiang ZouState Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China. zouliqiang2010@163.com.
Jing NiuState Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China. niujing28@sina.com.
Wei LiuState Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China. liuwei@ncu.edu.cn.
Sheng-Feng PengState Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China. psf01416@163.com.
Cheng-Mei LiuState Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China. chengmeiliu@yahoo.com.cn.
East China University of Technology · CNNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumin is a multifunctional and natural agent considered to be pharmacologically safe. However, its application in the food and medical industry is greatly limited by its poor water solubility, physicochemical instability and inadequate bioavailability. Nanoliposome encapsulation could significantly enhance the solubility and stability of curcumin. Curcumin nanoliposomes exhibited good physicochemical properties (entrapment efficiency = 57.1, particle size = 68.1 nm, polydispersity index = 0.246, and zeta potential = -3.16 mV). Compared with free curcumin, curcumin nanoliposomes exhibited good stability against alkaline pH and metal ions as well as good storage stability at 4 °C. Curcumin nanoliposomes also showed good sustained release properties. Compared with free curcumin, curcumin nanoliposomes presented an equal cellular antioxidant activity, which is mainly attributed to its lower cellular uptake as detected by fluorescence microscopy and flow cytometry. This study provide theoretical and practical guides for the further application of curcumin nanoliposomes.

Indexed as

AntioxidantsCaco-2 CellsCurcuminDelayed-Action PreparationsDrug StabilityEndocytosisHumansHydrogen-Ion ConcentrationIonsLiposomesMetalsMicroscopy, FluorescenceNanoparticlesParticle SizeSolventsSpectroscopy, Fourier Transform InfraredAntioxidantsCurcuminDelayed-Action PreparationsIonsLiposomesMetalsSolventscellular antioxidant activitycellular uptakecurcumin nanoliposomesstabilitysustained release

Identifiers

PMID26251892
PMCPMC6331986
OpenAlexW1927788755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.