Evidence map›Paper›PMID 26251870›Full record

ArticleThe ISME journal2016

Halobacteriovorax, an underestimated predator on bacteria: potential impact relative to viruses on bacterial mortality.

Henry N Williams, Despoina S Lymperopoulou, Rana Athar, Ashvini Chauhan, Tamar L Dickerson, Huan Chen, Edward Laws, Timkhite-Kulu Berhane, Adrienne R Flowers, Nadine Bradley and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Draft genome sequences of twoMicrobiology resource announcements · 2026
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  2. Review
  3. Enrichment isolation and metabolic characteristics ofApplied and environmental microbiology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Henry N WilliamsSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Despoina S LymperopoulouSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Rana AtharSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Ashvini ChauhanSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Tamar L DickersonSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Huan ChenSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Edward LawsSchool of the Coast & Environment, Department of Environmental Sciences, Louisiana State University, Baton Rouge, LA, USA.
Timkhite-Kulu BerhaneSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Adrienne R FlowersGulf Coast Research Laboratory, University of Southern Mississippi, Ocean Springs, MS, USA.
Nadine BradleySchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Shanterial YoungSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Denene BlackwoodInstitute of Marine Sciences, University of North Carolina at Chapel Hill, Morehead City, NC, USA.
Jacqueline MurraySchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Oladipupo MustaphaSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Cory BlackwellSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Yahsuan TungSchool of the Environment, Florida Agricultural and Mechanical University, Tallahassee, FL, USA.
Rachel T NobleInstitute of Marine Sciences, University of North Carolina at Chapel Hill, Morehead City, NC, USA.

Funding

Recruitment and HiringG12MD007582 · NIMHD · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI SOLIMAN, KARAM F.A. · 2012 to 2017
$16.0M
Targeted Nanocarrier Combination Based Therapy for Lung CancerP20MD006738 · NIMHD · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI SOLIMAN, KARAM F.A. · 2012 to 2016
$5.6M
NIMHD NIH HHS G12 MD007582NIMHD NIH HHS P20 MD006738
6 · The paper itself

Abstract

Predation on bacteria and accompanying mortality are important mechanisms in controlling bacterial populations and recycling of nutrients through the microbial loop. The agents most investigated and seen as responsible for bacterial mortality are viruses and protists. However, a body of evidence suggests that predatory bacteria such as the Halobacteriovorax (formerly Bacteriovorax), a Bdellovibrio-like organism, contribute substantially to bacterial death. Until now, conclusive evidence has been lacking. The goal of this study was to better understand the contributors to bacterial mortality by addressing the poorly understood role of Halobacteriovorax and how their role compares with that of viruses. The results revealed that when a concentrated suspension of Vibrio parahaemolyticus was added into microcosms of estuarine waters, the native Halobacteriovorax were the predators that responded first and most rapidly. Their numbers increased by four orders of magnitude, whereas V. parahaemolyticus prey numbers decreased by three orders of magnitude. In contrast, the extant virus population showed little increase and produced little change in the prey density. An independent experiment with stable isotope probing confirmed that Halobacteriovorax were the predators primarily responsible for the mortality of the V. parahaemolyticus. The results show that Halobacteriovorax have the potential to be significant contributors to bacterial mortality, and in such cases, predation by Halobacteriovorax may be an important mechanism of nutrient recycling. These conclusions add another dimension to bacterial mortality and the recycling of nutrients.

Indexed as

AntibiosisVirus Physiological PhenomenaBdellovibrioVibrio parahaemolyticusViruses

Identifiers

PMID26251870
PMCPMC4737939

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.