ArticleJournal of neurological surgery reports2015
Histoplasmosis with Deep CNS Involvement: Case Presentation with Discussion and Literature Review.
Article in Journal of neurological surgery reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- A comprehensive review of neurotropic fungal infections: clinical manifestations and vaccines.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- The brain pathobiome in Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Skull base infections, their complications, and management.The neuroradiology journal · 2024Review
- Article
- Central Nervous System Histoplasmosis: An Updated Insight.Pathogens (Basel, Switzerland) · 2023Article
- Article
- Intramedullary histoplasmosis of the thoracic cord as an isolated lesion: A rare case report and literature review.Surgical neurology international · 2023Article
- Article
- CNS Histoplasmosis as a Gliosarcoma mimicker: The diagnostic dilemma of solitary brain lesions.IDCases · 2022Article
- "Pseudo CNS Sarcoidosis": Histoplasmosis of Brain Mimicking Steroid Refractory Sarcoidosis.The Neurohospitalist · 2020Article
- A Case of Histoplasmosis with Central Nervous System Relapse after Itraconazole Therapy Needs Further Research.Cureus · 2020Article
- Article
- The Broad Clinical Spectrum of Disseminated Histoplasmosis in HIV-Infected Patients: A 30 Years' Experience in French Guiana.Journal of fungi (Basel, Switzerland) · 2019Review
- Article
- Fungal infections in pediatric neurosurgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Review
- Neuroinfections caused by fungi.Infection · 2018Review
- Diagnosing Ring-Enhancing Lesions in the Brain of a Patient With AIDS Without Brain Biopsy: A Case of Central Nervous System Histoplasmoma.The Neurohospitalist · 2018Article
- Article
- Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.Journal of medical microbiology · 2018Article
- Retrospective Analysis of Ventriculitis in External Ventricular Drains.Neurology research international · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) histoplasmosis is rare and difficult to diagnose because it is often overlooked or mistaken for other pathologies due to its nonspecific symptoms. A 32-year-old Hispanic man with advanced acquired immunodeficiency virus presented with altered mental status and reported confusion for the past 3 months. He had a Glasgow Coma Scale of 12, repetitive nonfluent speech, and a disconjugate gaze with a right gaze preference. Lung computed tomography (CT) findings indicated a pulmonary histoplasmosis infection. Magnetic resonance imaging of the brain revealed a ring-enhancing lesion in the left caudate nucleus. A CT-guided left retroperitoneal node biopsy was performed and indicated a benign inflammatory process with organisms compatible with fungal yeast. Treatment with amphotericin B followed by itraconazole was initiated in spite of negative cerebrospinal fluid (CSF) cultures and proved effective in mitigating associated CNS lesions and resolving neurologic deficits. The patient was discharged 3 weeks later in stable condition. Six weeks later, his left basal ganglia mass decreased. Early recognition of symptoms and proper steps is key in improving outcomes of CNS histoplasmosis. Aggressive medical management is possible in the treatment of intracranial deep mass lesions, and disseminated histoplasmosis with CNS involvement can be appropriately diagnosed and treated, despite negative CSF and serology studies.
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