Evidence map›Paper›PMID 26251713›Full record

ArticleClinical kidney journal2015

Membranous nephropathy in autologous hematopoietic stem cell transplant: autologous graft-versus-host disease or autoimmunity induction?

Ala Abudayyeh, Luan D Truong, Laurence H Beck, Donna M Weber, Katy Rezvani, Maen Abdelrahim

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ala AbudayyehDivision of Internal Medicine, Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston , TX , USA.
Luan D TruongDepartment of Pathology and Genomic Medicine , The Houston Methodist Hospital, Houston , TX , USA.
Laurence H BeckDepartment of Medicine, Section of Nephrology , Boston University School of Medicine, Boston , MA , USA.
Donna M WeberDepartment of Lymphoma/Myeloma , The University of Texas MD Anderson Cancer Center, Houston , TX , USA.
Katy RezvaniDepartment of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Maen AbdelrahimDivision of Medical Oncology, Duke University Medical Center , Durham, North Carolina , USA.
The University of Texas MD Anderson Cancer Center · USBoston University · USDuke Medical Center · USMethodist Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the increasing utility of hematopoietic stem cell transplantation (SCT) as a treatment for cancer and noncancerous disorders, more challenges and complications associated with SCT have emerged. Renal injury immediately after transplant is common and well understood, but long-term renal injury is becoming more evident. Chronic graft-versus-host disease (GVHD) is a known long-term complication of SCT, and membranous nephropathy (MN) is emerging as the most common cause of SCT-associated glomerular pathology. In this case report, we present a patient who developed features of anti-PLA2R antibody-negative MN following autologous SCT. The renal injury responded well to steroids and further response to rituximab therapy was noted, suggesting antibody-mediated autoimmune glomerular disease. We also present a review of the literature on autologous GVHD and the role of T and B cells in induction of autoimmunity by SCT.

Indexed as

anti-PLA2Rautologous stem cell transplantGVHDmembranous nephropathy

Identifiers

PMID26251713
PMCPMC4515891
OpenAlexW2173820821

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.