ArticleCancer and clinical oncology
The Insulin-like Growth Factor Axis, Adipokines, Physical Activity, and Obesity in Relation to Breast Cancer Incidence and Recurrence.
Article in Cancer and clinical oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Effects of exercise on inflammatory factors and IGF system in breast cancer survivors: a meta-analysis.BMC women's health · 2022Pooled it
- Feasibility of an exercise and nutritional intervention for weight management during adjuvant treatment for localized breast cancer: the PASAPAS randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Trial
- Bayesian Spatial Analysis of the Incidence Rate of Patients with Breast Cancer in Southern Iran.Iranian journal of medical sciences · 2025Article
- Investigating the trends of incidence rates of breast cancer in Southern Iran: a population based survey.BMC women's health · 2023Article
- Risk of breast cancer in men in relation to weight change: A national case-control study in England and Wales.International journal of cancer · 2022Article
- Frailty and aging in cancer survivors.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Use of consumer wearable devices to promote physical activity among breast, prostate, and colorectal cancer survivors: a review of health intervention studies.Journal of cancer survivorship : research and practice · 2020Review
- Oncologists' Perceptions of a Digital Tool to Improve Cancer Survivors' Cardiovascular Health.ACI open · 2019Article
- A review of home-based physical activity interventions for breast cancer survivors.Current cancer reports · 2019Article
- The Effects of Resistance Exercise on Biomarkers of Breast Cancer Prognosis: A Pooled Analysis of Three Randomized Trials.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Physical Activity, Weight Control, and Biomarkers of Prognosis and Survival among Breast Cancer Survivors.Archives of epidemiology · 2018Article
- Neurocalcin-delta: a potential memory-related factor in hippocampus of obese rats induced by high-fat diet.African health sciences · 2017Article
- A New Gene Expression Signature for Triple Negative Breast Cancer Using Frozen Fresh Tissue before Neoadjuvant Chemotherapy.Molecular medicine (Cambridge, Mass.) · 2017Article
- Article
- Postdiagnosis Weight Change and Survival Following a Diagnosis of Early-Stage Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Article
- Role of n-3 Polyunsaturated Fatty Acids and Exercise in Breast Cancer Prevention: Identifying Common Targets.Nutrition and metabolic insights · 2016Review
- Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study.PloS one · 2016Article
- The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics.International journal of endocrinology · 2016Article
- Serum irisin levels are lower in patients with breast cancer: association with disease diagnosis and tumor characteristics.BMC cancer · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObesity, a risk factor for the development of postmenopausal breast cancer and certain other cancer types, has also been associated with poorer response to cancer therapy and cancer recurrence. The insulin-like growth factor (IGF) axis also influences cancer risk.
methodsIn this commentary, we consider the literature on IGF and its binding proteins and the risk of breast cancer, along with effects of obesity, adipokines, and insulin resistance on breast cancer, and the potential for lifestyle interventions to address weight gain and physical inactivity among at-risk women.
resultsGreater body fatness is associated with a higher risk of postmenopausal breast cancer. The association may be explained, in part, by hyperinsulinemia and alterations in adipokines and estrogens. Nutrition, energy balance, and levels of physical activity are determinants of IGF bioactivity. Alterations in the IGF axis can increase cancer risk and progression. Results from epidemiologic studies indicate that higher circulating levels of IGF-I are associated with an increased risk of breast cancer.
conclusionsIntervention studies are needed to determine how to sustain the positive effects of exercise over time and to identify the optimal mode, intensity, frequency, duration, and timing of exercise for breast cancer survivors, including important subgroups of survivors such as African American and Hispanic women. Future epidemiologic studies of the relationships between the IGF axis and breast cancer should include adequate numbers of African American women, Hispanic women, and other minority women who have been underrepresented in studies completed to date.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.