Evidence map›Paper›PMID 26251588›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2015

Is asymptomatic peripheral arterial disease associated with walking endurance in patients with COPD?

Kuo-Shao Sun, Ming-Shian Lin, Yi-Jen Chen, Yih-Yuan Chen, Solomon Chih-Cheng Chen, Wei Chen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04627935 (The Effect of Foot Deformities on Physical Activity, Fatigue Level and Quality of Life in Elderly COPD Patients), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04627935 unknown statusnot on this mapstarted 2021, after this paper: background citation

The Effect of Foot Deformities on Physical Activity, Fatigue Level and Quality of Life in Elderly COPD Patients

TypeobservationalSponsorSultan Abdulhamid Han Training and Research Hospital, Istanbul, TurkeyRan2021 to 2021Enrolled77ConditionsChronic Obstructive Pulmonary Disease, Foot Deformities, Quality of Life, Activity, MotorArmsThe COPD Assessment Test, Navicular Drop Test, International Physical Activity Questionnaires (IPAQ), COPD and Asthma Fatigue Scale (CAFS), Saint George Respiratory Questionnaire
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Methods to assess atherosclerotic cardiovascular risk in chronic respiratory diseases: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kuo-Shao SunDivision of Pulmonary and Critical Care Medicine, Chang Gung University of Science and Technology, Taiwan, Republic of China ; Department of Respiratory Care, Chang Gung University of Science and Technology, Taiwan, Republic of China.
Ming-Shian LinDivision of Pulmonary and Critical Care Medicine, Chang Gung University of Science and Technology, Taiwan, Republic of China ; Department of Respiratory Care, Chang Gung University of Science and Technology, Taiwan, Republic of China.
Yi-Jen ChenDivision of Pulmonary and Critical Care Medicine, Chang Gung University of Science and Technology, Taiwan, Republic of China ; Department of Respiratory Care, Chang Gung University of Science and Technology, Taiwan, Republic of China.
Yih-Yuan ChenDepartment of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan, Republic of China.
Solomon Chih-Cheng ChenDepartment of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan, Republic of China.
Wei ChenDivision of Pulmonary and Critical Care Medicine, Chang Gung University of Science and Technology, Taiwan, Republic of China ; College of Nursing, Dayeh University, Changhua, Taiwan, Republic of China ; Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, Republic of China.
Chang Gung University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSymptomatic peripheral arterial disease (PAD) is associated with impaired walking endurance in patients with chronic obstructive pulmonary disease (COPD). However, it is unknown whether asymptomatic PAD is associated with impaired walking endurance in patients with COPD.

methodsThis prospective cross-sectional study enrolled 200 COPD patients (mean age: 70.9 years) who volunteered to perform ankle-brachial index (ABI) and 6-minute walk test (6MWT) consecutively. Demographic data, lung function, dyspnea scales, and cardiovascular risk factors were recorded. The ABI was used to detect PAD (ABI <0.90). All patients were free of PAD symptoms at enrollment.

resultsOf the 200 COPD patients, 17 (8.5%) were diagnosed with asymptomatic PAD. The COPD patients without asymptomatic PAD did not walk significantly further on the 6MWT than the COPD patients with asymptomatic PAD (439±86 m vs 408±74 m, P=0.159). The strongest correlation with the distance walked on the 6MWT was Medical Research Council dyspnea scale (r (2)=-0.667, P<0.001), followed by oxygen-cost diagram (r (2)=0.582, P<0.001) and forced expiratory volume in 1 second (r (2)=0.532, P<0.001). In multivariate linear regression analysis, only age, forced expiratory volume in 1 second, and baseline pulse oximetry were independently correlated with the distance covered on the 6MWT (P<0.05). However, body mass index, baseline heart rate, and ABI were not correlated with the distance covered on the 6MWT.

conclusionAsymptomatic PAD is not associated with walking endurance in patients with COPD. Therefore, it is important to detect and treat asymptomatic PAD early so that COPD patients do not progress to become exercise intolerant. Limited by the small sample size and predominantly male (99%) population in the study, further large-scale prospective studies are needed to verify the results.

Indexed as

Exercise ToleranceWalkingAgedAged, 80 and overAnkle Brachial IndexAsymptomatic DiseasesChi-Square DistributionCross-Sectional StudiesExercise TestFemaleForced Expiratory VolumeHumansLinear ModelsLungMaleMiddle Aged6-minute walk testsankle-brachial indexCOPDperipheral arterial disease

Identifiers

PMID26251588
PMCPMC4524389
OpenAlexW1926778170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.