SynthesisInternational journal of chronic obstructive pulmonary disease2015
Clinical characteristics of the asthma-COPD overlap syndrome--a systematic review.
Synthesis in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence of asthma-COPD overlap (ACO) in the general population: a systematic review and meta-analysis.Respiratory research · 2019Pooled it
- Article
- Transitions to and reversion from a persistent frequent-exacerbator state in COPD.ERJ open research · 2026Article
- A 3-year prospective study to assess clinical characteristics and risk factors for exacerbations in patients with asthma-COPD overlap based on the GINA guideline compared with patients with asthma and COPD.Respiratory research · 2026Article
- Clinical, Functional, and Psychosocial Profiles of Chronic Obstructive Pulmonary Disease (COPD) Etiotypes: A Taxonomy-Based Analysis.Medicina (Kaunas, Lithuania) · 2026Observational
- Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria.Journal of pharmaceutical policy and practice · 2026Review
- Physical, Mental, and Health Empowerment Disparities Across Chronic Obstructive Pulmonary Disease, Asthma, and Combined Groups and the Moderating Role of eHealth Literacy: Cross-Sectional Study.Journal of medical Internet research · 2025Article
- Established and Emerging Biological Therapies for the Treatment of Comorbid Asthma and Chronic Obstructive Pulmonary Disease.Journal of inflammation research · 2025Review
- Clinical Characteristics of T2-Low and T2-High Asthma-Chronic Obstructive Pulmonary Disease Overlap: Findings From COREA Cohort.Allergy, asthma & immunology research · 2024Article
- Psychometric Properties of the Short Scale Anxiety Sensitivity Index Among Adults with Chronic Respiratory Disease.Journal of clinical psychology in medical settings · 2024Article
- Respiratory symptoms, exacerbations and sleep disturbances are more common among participants with asthma and chronic airflow limitation: an epidemiological study in Estonia, Iceland and Sweden.BMJ open respiratory research · 2024Article
- β2-Adrenoceptor Agonists in Asthma or Chronic Obstructive Pulmonary Disease and Risk of Parkinson's Disease: Nested Case-Control Study.Clinical epidemiology · 2023Article
- Heterogeneity within and between physician-diagnosed asthma and/or COPD: NOVELTY cohort.The European respiratory journal · 2021Observational
- Update on Asthma-COPD Overlap (ACO): A Narrative Review.International journal of chronic obstructive pulmonary disease · 2021Review
- Prevalence of COPD among workers with work-related asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020Article
- Diagnosis and Treatment of Early Chronic Obstructive Lung Disease (COPD).Journal of clinical medicine · 2020Review
- Comorbidity profile of patients with concurrent diagnoses of asthma and COPD in Germany.Scientific reports · 2020Article
- Coexisting COPD Increases Mortality in Patients With Corticosteroid-Dependent Asthma: A Nationwide Population-Based Study.Allergy, asthma & immunology research · 2020Article
- Prevalence of self-reported sleep problems amongst adults with obstructive airway disease in the NHANES cohort in the United States.Sleep & breathing = Schlaf & Atmung · 2020Observational
- Acute exacerbations of COPD and risk of lung cancer in COPD patients with and without a history of asthma.European clinical respiratory journal · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveIn recent years, the so-called asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) has received much attention, not least because elderly individuals may present characteristics suggesting a diagnosis of both asthma and COPD. At present, ACOS is described clinically as persistent airflow limitation combined with features of both asthma and COPD. The aim of this paper is, therefore, to review the currently available literature focusing on symptoms and clinical characteristics of patients regarded as having ACOS.
methodsBased on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, a systematic literature review was performed.
resultsA total of 11 studies met the inclusion criteria for the present review. All studies dealing with dyspnea (self-reported or assessed by the Medical Research Council dyspnea scale) reported more dyspnea among patients classified as having ACOS compared to the COPD and asthma groups. In line with this, ACOS patients have more concomitant wheezing and seem to have more cough and sputum production. Compared to COPD-only patients, the ACOS patients were found to have lower FEV1% predicted and FEV1/FVC ratio in spite of lower mean life-time tobacco exposure. Furthermore, studies have revealed that ACOS patients seem to have not only more frequent but also more severe exacerbations. Comorbidity, not least diabetes, has also been reported in a few studies, with a higher prevalence among ACOS patients. However, it should be acknowledged that only a limited number of studies have addressed the various comorbidities in patients with ACOS.
conclusionThe available studies indicate that ACOS patients may have more symptoms and a higher exacerbation rate than patients with asthma and COPD only, and by that, probably a higher overall respiratory-related morbidity. Similar to patients with COPD, ACOS patients seem to have a high occurrence of comorbidity, including diabetes. Further research into the ACOS, not least from well-defined prospective studies, is clearly needed.
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