Evidence map›Paper›PMID 26251480›Full record

Trial reportPhysical therapy2016

Study of Hyperkyphosis, Exercise and Function (SHEAF) Protocol of a Randomized Controlled Trial of Multimodal Spine-Strengthening Exercise in Older Adults With Hyperkyphosis.

Wendy B Katzman, Eric Vittinghoff, Deborah M Kado, Anne L Schafer, Shirley S Wong, Amy Gladin, Nancy E Lane

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled TrialVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physical therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01751685 (Study of Hyperkyphosis, Exercise and Function-SHEAF), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01751685 nacompletednot on this map

Study of Hyperkyphosis, Exercise and Function-SHEAF

TypeinterventionalSponsorUniversity of California, San FranciscoRan2013 to 2019Enrolled99ConditionsKyphosisArmsKyphosis-specific spinal strengthening exercises, Control
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Effect of Therapeutic Exercise on the Management of Hyperkyphosis in Adolescence and Young Adulthood: A Systematic Review.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2025
    Pooled it
  2. Trial
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  5. Targeted spine strengthening exercise and posture training program to reduce hyperkyphosis in older adults: results from the study of hyperkyphosis, exercise, and function (SHEAF) randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Trial
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  7. Review
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  9. International consensus on the non-pharmacological and non-surgical management of osteoporotic vertebral fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Wendy B KatzmanW.B. Katzman, PT, DPTSc, OCS, Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, UCSF Box 0625, San Francisco, CA 94143-0625 (USA). wendy.katzman@ucsf.edu.
Eric VittinghoffE. Vittinghoff, PhD, Department of Epidemiology and Biostatistics, University of California, San Francisco.
Deborah M KadoD.M. Kado, MD, MS, Departments of Family Medicine and Public Health and Internal Medicine, University of California, San Diego, California.
Anne L SchaferA.L. Schafer, MD, Department of Epidemiology and Biostatistics and Department of Medicine, University of California, San Francisco, and Medical Service, San Francisco Veterans Affairs Medical Center, San Francisco, California.
Shirley S WongS.S. Wong, BS, Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco.
Amy GladinA. Gladin, PT, MPT, DPT, OCS, Kaiser Permanente Northern California, San Francisco Medical Center, San Francisco, California.
Nancy E LaneN.E. Lane, MD, Department of Internal Medicine, University of California, Davis, Davis, California.
University of California, San Francisco · USBiostatistical Consulting (United States) · USKaiser Permanente San Francisco Medical Center · USSan Francisco VA Medical Center · USUniversity of California, Davis · USUniversity of California System · US

Funding

Sex Differences in response to an exercise for hyperkyphosisP50AR063043 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LANE, NANCY E · 2012 to 2017
$5.7M
Study of Hyperkyphosis, Exercise and Function - SHEAFR01AG041921 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATZMAN, WENDY BETH · 2012 to 2016
$2.4M
Effects of Gastric Bypass Surgery on Calcium Metabolism and the SkeletonIK2CX000549 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI SCHAFER, ANNE LOUISE · 2011 to 2015
–
CSRD VA IK2 CX000549NIAMS NIH HHS P50 AR063043NIA NIH HHS R01 AG041921
6 · The paper itself

Abstract

backgroundHyperkyphosis negatively affects health status, physical mobility, and quality of life, but there is no standard protocol for treating people with hyperkyphosis. Treatment options include targeted exercise.

objectivesThis single-site randomized controlled trial (RCT) will determine the efficacy of a targeted multimodal spine-strengthening exercise program, compared with no exercise intervention, among community-dwelling men and women aged ≥60 years.

designThe RCT is a parallel-group design, with 1:1 randomization to exercise and attentional control groups.

settingThe study will be conducted at one primary site (one academic medical center partnered with one local community medical center).

participantsOne hundred men and women, aged ≥60 years, with thoracic kyphosis ≥40 degrees will be randomized.

interventionThe targeted multimodal spine-strengthening exercise intervention includes exercise and postural training delivered by a physical therapist in a group of 10 participants, 3 times a week for 6 months. Controls receive monthly health education meetings in a group of 10 participants and monthly calls from the study coordinator to monitor physical activity and any adverse events. MEASUREMENTS: The primary outcome is change in Cobb angle of kyphosis measured from lateral spine radiographs at baseline and 6 months. Secondary outcomes include change in physical function (assessed with the modified Physical Performance Test, Timed "Up & Go" Test, timed loaded standing, 4-m walk, and Six-Minute Walk Test) and health-related quality of life (assessed with the modified Scoliosis Research Society instrument [SRS-30] self-image domain and Patient Reported Outcomes Measurement Information System [PROMIS] global health and physical function indexes). Additional secondary outcomes include pain, physical activity level, spinal flexion and extension muscle strength, paraspinal extensor muscle density, and adverse events. LIMITATIONS: Blinding of the participants and instructors providing the intervention is not possible.

conclusionsThe efficacy of a high-quality, adequately powered exercise intervention in men and women with kyphosis ≥40 degrees will be evaluated to determine whether targeted multimodal spine-strengthening exercise reduces hyperkyphosis in older adults and improves important secondary outcomes of physical function and health-related quality of life.

Indexed as

AgedExercise TherapyFemaleHumansKyphosisMaleMiddle AgedSingle-Blind MethodTreatment Outcome

Identifiers

PMID26251480
PMCPMC4774389
OpenAlexW2153682770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.