ArticleJournal of the American Society of Nephrology : JASN2016
Kidney Function and Cerebral Blood Flow: The Rotterdam Study.
Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Renal Function and Efficacy of Remote Ischemic Conditioning in Acute Moderate Ischemic Stroke: A Post Hoc Analysis of RICAMIS Trial.Brain and behavior · 2025Trial
- Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Trial
- Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults.Neurology · 2016Trial
- Prognostic Factors in Acute Ischemic Stroke With a Decreased Estimated Glomerular Filtration Rate.Brain and behavior · 2026Article
- Does low-temperature dialysis still represent an advantage?: a narrative review from the last decade.International urology and nephrology · 2026Review
- Observational
- Intradialytic cerebral blood flow reduction occurs irrespective of vascular access type: a comparative study.BMC nephrology · 2026Article
- Cerebral Blood Flow and Cognition in CKD: A Physiological Paradox.Journal of the American Society of Nephrology : JASN · 2025Article
- Chronic kidney disease and dementia: an epidemiological perspective.Nature reviews. Nephrology · 2025Review
- Article
- Renal function and efficacy of dual antiplatelet vs. alteplase in minor stroke: aFrontiers in neurology · 2025Article
- The Joint Effect of Renal Function Status and Coagulation Biomarkers on In-Hospital Outcomes in Acute Ischemic Stroke Patients With Intravenous Thrombolysis.Immunity, inflammation and disease · 2024Article
- Epidemiology and Risk Factors for Stroke in Chronic Kidney Disease: A Narrative Review.Biomedicines · 2023Review
- Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease.Journal of personalized medicine · 2023Article
- Evidence of Brain Alterations in Noncerebral Falciparum Malaria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Cerebral oxygenation and body mass index association with cognitive function in chronic kidney disease patients without dialysis: a longitudinal study.Scientific reports · 2022Article
- Elevated Intrarenal Resistive Index Predicted Faster Renal Function Decline and Long-Term Mortality in Non-Proteinuric Chronic Kidney Disease.Journal of clinical medicine · 2022Article
- The effect of systemic factors on retinal blood flow in patients with carotid stenosis: an optical coherence tomography angiography study.GeroScience · 2022Article
- Covert vascular brain injury in chronic kidney disease.Frontiers in neurology · 2022Review
- Impact of Chronic Kidney Disease on Brain Structure and Function.Frontiers in neurology · 2022Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CKD is linked with various brain disorders. Whereas brain integrity is dependent on cerebral perfusion, the association between kidney function and cerebral blood flow has yet to be determined. This study was performed in the framework of the population-based Rotterdam Study and included 2645 participants with mean age of 56.6 years (45% men). We used eGFR and albumin-to-creatinine ratio to assess kidney function and performed phase-contrast magnetic resonance imaging of basilar and carotid arteries to measure cerebral blood flow. Participants had an average (SD) eGFR of 86.3 (13.4) ml/min per 1.73 m(2) and a median (interquartile range) albumin-to-creatinine ratio of 3.4 (2.2-6.1) mg/g. In age- and sex-adjusted models, a higher albumin-to-creatinine ratio was associated with lower cerebral blood flow level (difference in cerebral blood flow [milliliters per minute per 100 ml] per doubling of the albumin-to-creatinine ratio, -0.31; 95% confidence interval, -0.58 to -0.03). The association was not present after adjustment for cardiovascular risk factors (P=0.10). Each 1 SD lower eGFR was associated with 0.42 ml/min per 100 ml lower cerebral blood flow (95% confidence interval, 0.01 to 0.83) adjusted for cardiovascular risk factors. Thus, in this population-based study, we observed that lower eGFR is independently associated with lower cerebral blood flow.
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